荜茇不皂化物对家兔胆汁成分及谷丙转氨酶的影响  

Effects of unsaponifiable matter of Fructus Piperis on bile components and levels of ALT in rabbits

作　　者：乌勒彩拉[1] 乌云格日乐[1] 陈塔娜[1] 

机构地区：[1]内蒙古医学院,呼和浩特010110

出　　处：《中国民族医药杂志》2008年第12期43-44,共2页Journal of Medicine and Pharmacy of Chinese Minorities

摘　　要：目的:观察荜茇不皂化物对家兔胆汁成分及谷丙转氨酶水平的影响,为进一步开发研制治疗高脂血症的蒙药提供实验依据。方法:用全自动生化仪测定用药前后家兔胆汁中胆酸、胆固醇含量及血清谷丙转氨酶的变化。结果:①静注荜茇不皂化物乳剂,给药前后胆固醇比较有显著差异(P<0.05);给药前后胆汁酸比较有显著差异(P<0.05);②正常组和不同剂量不皂化物组兔谷丙转氨酶比较无统计学意义(P>0.05)。结论:荜茇不皂化物能抑制家兔肝脏合成胆固醇,促进胆汁酸的生成,对谷丙转氨酶没有显著影响。Objective： To observe the impact of unsaponifiable matter of Fructus Piperis on bile components and levels of ALT in experimental rabbits, and therefore to provide a theoretical basis for studying Mongolian Medicine on Hyperlipidemia. Methods：①Tbe contents of bilea cids and Cholesterol were measured before and after using unsaponifiable matter of Fructus Piperis by ACA. ②the changes of ALT were measured by ACA. Results： ①Unsaponifiable matter of Fructus Piperis for IV injection, before and after the treatment, Both of cholesterol and total bile acids between the two groups were significantly different （ P 〈 0.05）. ② There were no statistical significance in ALT between the control group and gruop of different dosages of unsaponifiable matter（ P 〉 0.05）. Conclusions： We found that unsaponifiable matter of Fructus Piperis can inhibit liver to synthesis cholesterol and to accelerate produce bile acids.

关 键 词：荜茇不皂化物 胆固醇 胆汁酸 谷丙转氨酶 

分 类 号：R291.2[医药卫生—民族医学]