镉中毒时肾细胞内微量元素含量的改变  

Changes in Trace Elements Contents of Renal Cells in Cadmium Poisoning

作　　者：龙曼海[1,2,3,4,5,6] 赵金垣[1,2,3,4,5,6] 王世俊[1,2,3,4,5,6] 邵涵如 刘亚宁[1,2,3,4,5,6] 刘爱萍 

机构地区：[1]北京医科大学 [2]贵阳医学院预防医学系 [3]北京医科大学第三医院职业病研究中心 [4]中国科学院高能物理研究所 [5]空军总医院检验科发光室 [6]包头医学院卫生系

出　　处：《中华预防医学杂志》1998年第2期73-75,共3页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金

摘　　要：目的了解微量元素在镉中毒性肾损伤中的作用及机制。方法制备镉中毒性肾损伤的动物模型，测定了肾细胞亚细胞成分中微量元素的含量、脂质过氧化反应及肾功能、超微结构的改变。结果镉的摄入使主要分布于线粒体的铜、锌、锰向胞核和胞浆转移，而线粒体、胞液中硒含量与谷胱甘肽过氧化物酶活性均降低，丙二醛则升高。结论提示镉性肾损伤时微量元素尤其是硒的改变可能与脂质过氧化反应增强有关，细胞内微量元素分布异常也可能是影响镉性肾损伤的重要因素之一。Objective To understand the possible role of trace elements in renal damage caused by cadmium poisoning and its mechanism. Methods An experimental animal model with renal damage caused by cadmium poisoning was prepared, and trace elements contents in subcellular components in renal cells, lipid peroxidation reaction, renal function and its ultrastructural changes were determined. Results Uptake of cadmium could cause transfer of copper, zinc and manganese mainly distributed in the mitochondrion to cell nuclei and cytoplasm, and content of selenium and activity of glutathione peroxidase (GSH px) in cytosol declined and content of propandiolal increased. Conclusion It suggests that changes in trace elements contents, especially in selenium content, during renal damage caused by cadmium poisoning, could correlate with the increase of lipid peroxidation, and abnormal subcellular distribution of trace elements was one of the important roles in renal damage caused by cadmium poisoning.

关 键 词：镉中毒 肾损伤 微量元素 肾细胞 

分 类 号：R595.2[医药卫生—内科学] R995[医药卫生—临床医学]