夜间哮喘发病的自由基机理研究  

Study on the pathogenesis of free radical in nocturnal asthma

作　　者：哈木拉提 阿布都艾尼 阿布都热依木 庞辉群 

机构地区：[1]乌鲁木齐新疆维吾尔医学研究所基础医学研究室

出　　处：《中华结核和呼吸杂志》1998年第3期141-143,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的探讨夜间哮喘发病与自由基的关系。方法应用细胞化学发光分析技术动态检测夜间哮喘淋巴细胞发光强度（Ｌｙ－ｃｌ）和多形核白细胞发光强度（ＰＭＮ－ｃｌ）的变化；同时检测全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力和血浆丙二醛（ＭＤＡ）浓度。结果夜间哮喘患者Ｌｙ－ｃｌ及ＰＭＮ－ｃｌ次日２∶００时较当日１４∶００时增强（Ｐ＜０．０１），与对照组比较差异有显著性（Ｐ＜０．０１）；而ＧＳＨ－Ｐｘ活力下降（Ｐ＜０．００１），ＭＤＡ含量增高（Ｐ＜０．０１）。结论夜间哮喘患者外周血自由基代谢具有明显的昼夜差异。Objective To examine the relationship between the pathogenesis of nocturnal asthma and free radicals. Method The changes of the chemiluminescence of lymphocytes (Ly cl) and polymorphonuclear leukocytes (PMN cl) were studied by the cell chemiluminescence method. Glutathione peroxidase (GSH Px) and malondialdehyde (MDA) levels also were determined respectively. Result The Ly cl and PMN cl in patients with nocturnal asthma on the second day 2∶00 am were significantly higher than that of the second day 2∶00 pm ( P <0.01) and higher than that of normal group ( P <0.01). The GSH px were decreased and MDA were increased, and there were significant differences compared with normal group ( P <0.001, P <0.01 respectively). Conclusion There is an obvious difference on metabolism of free radicals on day and night in nocturnal asthma. The results support that the free radicals have an important role in pathogenesis of nocturnal asthma.

关 键 词：夜间哮喘 自由基 细胞化学发光 哮喘 

分 类 号：R562.250.2[医药卫生—呼吸系统]