葡萄糖对35%TBSAⅢ°烫伤大鼠肠内补液时吸收率影响的研究  

THE EFFECT OF GLUCOSE ABSORBANCE ON BIG RATS WITH 35% TBSA SCALD DURING ENTERAL RESUSCITATION

作　　者：任明姬[1] 耿世佳[1] 孙红[1] 胡森[2] 

机构地区：[1]内蒙古医学院基础医学院,内蒙古呼和浩特010059 [2]解放军总医院第一附属医院

出　　处：《内蒙古医学院学报》2008年第6期420-423,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自然科学基金(200607010909)

摘　　要：目的:研究葡萄糖对35%TBSAⅢ°烫伤大鼠肠内补液时小肠电解质溶液吸收率的影响。方法:雄性Wistar大鼠30只,随机分为:假烫补林格氏液组(假烫LR组,n=10);烫伤补林格氏液组(烫伤LR组,n=10)和烫伤补葡萄糖-林格氏液组(烫伤LR/G组,林格氏液中加入20g/L的葡萄糖粉,n=10)。烫伤组采用沸水法(100℃,15 s)造成35%TBSAⅢ°烫伤。各组于烫伤后0.5h按1/2派克兰公式量和速率(2mL/kg.1%TBSA-1)进行肠内补液。测定烫伤后4h内肠道对水分和Na+的吸收率,以及伤后4h肠黏膜血流量和Na+-K+-ATP酶活性。结果:烫伤LR组小肠对水和Na+的吸收率明显下降(P<0.05);两烫伤组之间比较,烫伤LR/G组对水和Na+的吸收优于烫伤LR组,在伤后2h有显著差别(P<0.05);伤后4h烫伤LR/G组肠黏膜血流量和Na+-K+-ATP酶活性也显著高于烫伤LR组(P<0.05)。结论:35%TBSAⅢ°烫伤大鼠肠内补液时,小肠对葡萄糖电解质溶液的吸收率明显下降;葡萄糖可以提高烫伤休克肠内复苏时小肠的吸收率,并且与提高肠黏膜血流量和Na+-K+-ATP酶活性有关。Objective ：To investigate the effects of glucose on electrolyte absorbance during enteral resuscitation in scald rats, and evaluate the effects of glucose on the enteral absorption of electrolyte and water. Methods：Male Wistar rats （n = 30） were randomly divided into three groups：sham scald with enteral Ringer＇s solution（ sham LR, n = 10）, scald with enteral LR（ scald LR, n = 10 ）, and scald with enteral LR containing 20g/L glucose group （scald LR/G, n = 10）. About 35% TBSA of scald rats were produced with boiling water（ 100℃ ,15s）. The amount and speed of infusion of resuscitation fluid were estimated according to 1/2 of Parkland formula（2mL/kg·1% TBSA^-1） within 0. 5h after injury. During the first 4 hours after scald, enteral absorption rate of water and Na^＋ were continuously assessed. Intestinal mucosa blood flow and the activity of Na^＋ -K^＋ -ATPase was determined. Results： The enteral absorbance of water and Na^＋ in scald LR were significantly decreases （P〈0. 05） ; The intestinal absorption rate of water and Na^＋ in scald LR/G group were significantly enhanced compared to those in scald LR group from 2h after injury （P〈0.05） ; There was also much significant higher of intestinal mucosa blood flow and activity of Na^＋ -K^＋ -ATPase in scald LR/G group than that in scald LR group at 4h after scald. Conclusion：The results indicated that 35% TBSA of scald injury can lead to lowering the gut absorption rate of water and Na^＋ in rats. Enteral resuscitation with the glucose-electrolyte solution is superior to electrolyte solution only in its improvement of intestinal absorption and the activity of Na^＋ -K^＋ -ATPase.

关 键 词：烫伤 肠内复苏 葡萄糖 肠吸收 

分 类 号：R969.2[医药卫生—药理学]