原发性干燥综合征合并自身免疫性甲状腺病  

Autoimmune thyroid disease in primary Sjgren syndrome

作　　者：冯学兵[1] 张华勇[1] 周康兴[1] 

机构地区：[1]南京大学医学院附属鼓楼医院风湿免疫病科,210008

出　　处：《江苏医药》2009年第1期72-74,共3页Jiangsu Medical Journal

摘　　要：目的了解合并自身免疫性甲状腺病的原发性干燥综合征(pSS)临床特点。方法检测41例住院治疗的pSS患者甲状腺功能、甲状腺抗体,比较pSS中甲状腺功能正常者与合并自身免疫性甲状腺病者临床特征。结果41例pSS患者中女性39例(95.1%),平均发病年龄42.6岁;甲状腺功能异常18例(43.9%),其中13例甲状腺功能减低,5例甲状腺功能亢进;7例诊断为自身免疫性甲状腺病(桥本甲状腺炎4例,Graves病3例)。与甲状腺功能正常的患者相比,合并自身免疫性甲状腺病的pSS患者甲状腺肿大发生率增高(P<0.01),同时血红蛋白降低而球蛋白或IgG增高(P<0.05)。结论PSS合并自身免疫性甲状腺病并不少见,对于存在高球蛋白血症和贫血的患者应常规进行甲状腺功能和抗体检测。Objective To study the clinical features of primary Sjoegren syndrome （pSS） in patients with autoimmune thyroid disease. Methods Thyroid function and thyroid antibodies of 41 pSS cases were measured. Clinical manifestations and laboratory results of those with normal thyroid function and those with autoimmune thyroid disease were analyzed. Results Among 41 pSS patients, 95.1% was female with average onset age of 42.6 years old. Eighteen patients （43.9%） had abnormal thyroid function, of which 13 cases were hypothyroidism and 5 were hyperthyroidism. Seven cases were diagnosed with autoimmune thyroid disease, including four with Hashimoto thyroiditis and three with Graves＇s disease. As compared to the pSS patients with normal thyroid function, enlarged thyroid, decreased hemoglobin and elevated globulin or IgG were found to be more prominent in those accompanied with autoimmune thyroid disease （P〈 0. 05 ）. Conclusion Autoimmune thyroid disease is common in pSS. Those with anemia and hyperglobulinemia should be routinely tested for thyroid function and its antibodies.

关 键 词：原发性干燥综合征 自身免疫性甲状腺病 

分 类 号：R593[医药卫生—内科学]