水溶性维生素粉针与葡萄糖酸钙防治草酸铂神经毒性60例  

Prevention and treatment of oxaliplatin-induced neurotoxicity with Soluvit plus calcium gluconate

作　　者：张明[1] 谢可[1] 吴琦[1] 

机构地区：[1]四川省人民医院肿瘤科,四川成都610071

出　　处：《中国医刊》2009年第1期27-28,共2页Chinese Journal of Medicine

摘　　要：目的评价水乐维他、葡萄糖酸钙防治草酸铂神经毒性的疗效。方法 FOLFOX4方案:奥沙利铂85mg/m^2静滴2小时,第1天;四氢叶酸钙200mg/m^2,静滴2小时,第1、2天;氟尿嘧啶400mg/m^2静注,第1、2天;氟尿嘧啶600mg/m^2中心静脉注射22小时。2周重复。60例大肠癌患者随机分成2组,每组30例。分别观察水乐维他+葡萄糖酸钙(A 组)与对照组(B 组)的草酸铂神经毒性。结果 A 组、B 组的草酸铂神经毒性发生率分别为30.00%和46.67%,差异有显著性意义。结论水乐维他+葡萄糖酸钙可以减少草酸铂的神经毒性发生,缓解神经毒性症状。Objective To evaluate the clinical effects of Soluvit and calcium gluconate on oxaliplatin （L-OHP）-induced neurotoxicity. Methods L-OHP 85 mg/m^2, ivgtt, d1; leucovorin （CF） 200mg/m^2, ivgtt, d1-2 ;5-Fu 400mg/m^2,iv ,5-Fu 600mg/m^2, ivgtt CIV 22 h, every 14d. After chemotherapy, sixty coloreetalcancer patients were randomly divided into A or B group. The patients of group A received Soluvit for 7days and calcium glueonate 2 g/d,for 5 days. B was control group . All patients were evaluated for peripheral sensory neurotoxieity and rated according to the oxaliplatin specific scale. Results The incidence rate of L-OHP induced neurotoxicity of the groupA, B was 30.00% and 46.67%. Conclusion Combined Soluvit and calciumion may be effective in preventing and overco- ming LOHP-induced neurotoxity.

关 键 词：草酸铂 神经毒性 水乐维他 葡萄糖酸钙 

分 类 号：R979.1[医药卫生—药品]