耐亚胺培南铜绿假单胞菌耐药性的检测与分析  

Surveillance of imipenem-resistant Pseudomonas aeruginosa in Patients of our hospital

作　　者：曾峰[1] 潘桂常[1] 林雅[1] 田东波[1] 向镜芬[1] 

机构地区：[1]暨南大学医学院第五附属医院清远市人民医院,广东清远511500

出　　处：《广东医学院学报》2008年第6期606-608,共3页Journal of Guangdong Medical College

基　　金：清远市科委立项(No.2008B0005)

摘　　要：目的分析我院耐亚胺培南铜绿假单胞菌(IRPA)的发生率及对其他抗生素耐药性的变迁。方法收集我院2002年1月至2007年12月分离的铜绿假单胞菌的药物敏感试验结果。结果2005-2007年间IRPA检出率(40.2%)明显高于2002-2004年(29.5%)(P<0.01),其中痰标本中分离的菌株最多。2002-2004年IRPA对β-内酰胺类、喹诺酮类和氨基甙类均耐药,2005-2007年IRPA对庆大霉素和头孢哌酮舒巴坦的耐药性显著上升(P<0.01)。结论IRPA发生率呈上升趋势,其对多种抗生素的耐药性也有上升趋势,提示在临床上合理应用抗生素极为重要。Objective To analyze the prevalence of imipenem-resistant Pseudomonas aeruginosa （IRPA） and the change of its resistance to other antibiotics in our hospital. Methods The isolated strains of IRPA were detected by drug sensitivity test in between January 2002 and December 2007. Results The prevalence of IRPA during 2005 - 2007 was significantly higher than that during 2002 - 2004 （40.2 % vs29.5 %, P 〈 0.01）, and most of IRPA strains were isolated from sputa. The isolated strains of IRPA were resistant to β-1actam antibiotics, fluoroquinolones and aminoglyoosides during 2002 - 2004, and their resistance to gentamicin and cefoperazone-sulbactam tended to upgrade between 2005 - 2007 as compare with that between 2002 - 2004 （P〈0.01）. Conclusion The prevalence of IRPA and its resistantce to other antibiotics is increasing, indicating that rational use of antibiotics is very important in the clinical practice.

关 键 词：铜绿假单胞菌 亚胺培南 耐药性 

分 类 号：R378.99[医药卫生—病原生物学]