血清同型半胱氨酸与冠心病患者及多项生化指标关系的分析  

The analysis of the relationship between serum homocysteine(HCY) and chemistries in patients of coronary heart disease

作　　者：荣嵘[1] 张爱民[1] 樊春红[1] 张正[1] 

机构地区：[1]北京大学人民医院检验科,北京100044

出　　处：《中国实验诊断学》2009年第1期77-80,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨冠心病患者血清同型半胱氨酸(HCY)浓度与多项生化指标间的关系。方法检测263例冠心病患者和152名健康者的HCY浓度及多项生化指标。结果①全部患者组与对照组HCY、UN、SCr、UA、FBG、TG、HDL-C、CK、LDH、hsCRP、FA、VitB12均有显著差异P<0.01;②单纯冠心病组、冠心病合并高血压组与对照组间HCY浓度均有显著性差异P<0.01,冠心病合并高血压组与单纯冠心病组比较HCY浓度有显著性差异,P<0.05;③冠状动脉病变支数<3支组和>3支组,HCY浓度均与健康对照组有显著性差异P<0.01;④不稳定心绞痛、急性心梗、慢性心梗三组,HCY浓度均与健康对照组有显著性差异P<0.01;⑤Ⅰ级、Ⅱ级、Ⅲ级高血压患者HCY分别与对照组HCY相比均有显著性差异P<0.01;⑥以HCY为应变量,依次进入方程的变量为UN、VitB12、高血压史、性别、TG、FBG、LDH。R值为0.519,R2为0.27,P值<0.01;⑦HCY与UN、SCr、UA、TG、HDL-C、CK、LDH、VitB12、FA均有相关性。相关系数分别为:0.318、0.29、0.313、0.162、-0.217、0.149、0.162、-0.153、-0.138。结论监测血清HCY等实验的浓度变化及各项生化指标的关系,对冠心病治疗诊断有十分重要的临床价值。Objective To investigate the relationship between serum HCY levels and chemistries in patients of coronary heart disease.Methods Serum HCY levels and chemistries were studied in263 CHD patients and 152 controls.Results （Din comparison all patients with normal serum：the concentrations of HCY, UN,SCr, UA, FBG,TG,HDL-C,CK,LDH,hsCRP, FA,VitB12 were signif- icantly different： P 〈 0.01 ; （2）The concentrations of HCY were higher in CHD,the group of CHD and hypertension than in controls P 〈 0.01. There was significant difference between the two groups P 〈 0.05; （3）The patients were divided into two groups： 〈 3 lesions and 〉 3 lesions. The levels of HCY were markedly higher than in controls P 〈 0.01 ;（4）The patients were divided into three groups： UAP,AMI and CMI. The levels of HCY were markedly higher than in controls P 〈 0.01 ;（5）Levels of HCY with Ⅰ , Ⅱ, Ⅲ classes hypertensive patients were markedly higher than in controls P 〈 0.01 ; （6）UN, VitB12, history of hypertension, sex, TG, FBG, LDH changed according to orders when HCY was dependent. R = 0. 519, R2 = 0.27, P 〈 0.01 ; （7）There were relations between HCY and UN,SCr, UA,TG,HDL-C,CK,LDH,VitB12, FA.The relative coefficient were：r= 0.318,0.29,0.313,0.162, - 0.217,0.149,0. 162, -0.153, -0.138. Conclusion It strongly suggests that to monitor and control the plasma concentrations of HCY and other chemistries in patients with CHD have an active clinical meaning to diagnose and treat CHD.

关 键 词：血清 同型半胱氨酸 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]