1874例宫颈液基细胞学涂片检查结果与宫颈活检对比分析  

A Comparing Analysis of 1 874 Uterine Cervical Liquid based Cytology Smears and Cervical Biopsy

作　　者：战伟[1] 陈世范[1] 杨媚[1] 姚敏[1] 赵孟禹[1] 高洪文[1] 

机构地区：[1]吉林大学第二医院病理科,吉林长春130041

出　　处：《中国实验诊断学》2009年第1期94-96,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的分析门诊患者宫颈病变特点及病变组成比例,探讨宫颈LPC涂片的细胞学诊断的准确性。方法复习吉林大学第二医院病理科2007年1月1日-2007年4月30日期间1 874例宫颈LPC细胞涂片(Pap染色),按照TBS标准进行细胞学诊断,统计分析细胞学诊断结果,分析宫颈病变的特点,对照活检组织病理诊断结果,分析细胞学诊断结果的准确率。结果①检出癌症及癌前病变73例,检出率为3.9%,其中鳞状细胞癌(SCC)14例,高度鳞状上皮内病变(HSIL)15例,低度鳞状上皮内病变(LSIL)24例(其中10例见有挖空细胞),意义不明确的非典型鳞状细胞(ASCUS)17例,腺癌2例,不典型腺上皮细胞1例。73例中有56例进行了组织病理学检查,符合率为86.67%。②1801例阴性病例中滴虫感染25例(1.39%),真菌感染11例(0.61%),细菌性阴道病(Bacterial Vaginosis,BV)102例(5.66%),单纯疱疹病毒感染1例。结论应用LPC薄层细胞技术检查宫颈LSIL、HSIL与SCC特异性较高,同时能检出相对特异性的炎症性疾病。Objective to investigate the characteristic of the outpatients＇ cervical lesions and evaluate the diagnostic accuracy of LPC by comparing these date with the results of cervical biopsy. Methods retrospectively reviewed tile 1 874 cases of cervical LPC smears which the Department of Obstetrics and Gynecology has submitted for screening within four months from January 1,2007 to April 30,2007.Results （1）Of the 1 874 LPC patient smears,73（3.9% of the total） identified carcinomas or precancerous lesions. （2）The 73 positive eases included 14 squamous cell carcinomas （SCC）,15 preparations with high-grade squamons intraepithelial lesions （HSIL） ,24 eases of low-grade squamous intraepithelial lesions （LSIL）, 17 patients with atypical squamous cells of undetermined significance （ASCUS）,2 cases of adenocarcinoma （AC）,and 1 patient with atypical glandular cells （AGC）.（3） Twenty five of the 1801 cases without intra-epithelial or malignant lesions （ 1.39% ） had infection with Triehomonas species. There were 11 cases （0.61% ） of infection by Candida albieans, 102 cases （5.66%） of bacterial vaginopathy,and I case of Herpes simplex virus infection. Conclusion Using LPC thin-layer preparation to assess the uterine cervix, there is high specificity for cytological diagnoses of LSIL, HSIL and SCC. We have also shown that some specific inflammatory diseases can also be detected by uterine cervical LPC smears.

关 键 词：液基薄层细胞学 宫颈病变 人乳头瘤状病毒 

分 类 号：R446.8[医药卫生—诊断学]