体外受精-胚胎移植治疗PCOS不孕分析  

The treatment of patients with polycystic ovarian syndrome by in vitro fertilization and embryo transfer.

作　　者：吴成平[1] 谷玉[1] 李静[1] 赵芳[1] 

机构地区：[1]洛阳市妇女儿童医疗保健中心生殖医学研究所,河南471000

出　　处：《中国优生与遗传杂志》2009年第1期91-92,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的评价体外受精-胚胎移植(IVF-ET)治疗多囊卵巢综合征(PCOS)伴不孕的疗效。方法对2002年5月至2006年4月在本中心行IVF-ET或ICSI的PCOS患者资料回顾分析。A组为PCOS患者29周期,B组(对照组)为同期输卵管阻塞性不孕患者155周期。结果A组获卵数、胚胎数显著多于B组(P<0.01),OHSS发生率和移植取消率显著高于B组(P<0.05);A组年龄、促排卵药总量、优质胚胎率显著低于B组(P<0.01);两组不孕年限、HCG日E2水平、刺激时间、受精率、妊娠率、移植日内膜厚度均无显著差异。结论PCOS患者行IVF/ICSI-ET治疗时Gn用量少,获卵数多,胚胎数多,但优质胚胎率低;OHSS发生高危,取消移植率高;临床妊娠率、受精率与输卵管阻塞性不孕患者无显著差异。对于PCOS患者,IVF/ICSI-ET可以有效助孕。Objective ： To evaluate the effect of in vitro fertilization - embryo transfer （ IVF - ET） or introcytoplasmicsperm injection （ICSI） in the infertile patients with polycystic ovarian syndrome （PCOS）. Methods： The infertile patients with PCOS who underwent IVF - ET or ICSI from May 2002 to April 2006 were retrospectively studied. PCOS patients （29 cycles） served as group A and non - P- COS patients with infertility due to tubal occlusion （155 cycles） as control （group B）. Results： The number of oocytes retrieved and cleavage embryos and the rates of OHSS and cancelled ET were higher in PCOS group （ P 〈0. 01, P 〈0. 05）. However patients ages, amps of Gn, the rate of top quality embryos, the duration of infertility and stimulation, the level of E2 on the day of HCG injection, the rates of fertilization and pregnancy, and the thickness of endometrium were compared between the two groups. Conclusions ： IVF/ICSI - ET is an effective management for the infertile patients with PCOS after conventional methods failed to be conceived.

关 键 词：多囊卵巢综合征 体外受精-胚胎移植 卵巢过度刺激综合征 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]