2000-2005年自北京儿童医院门诊患儿鼻咽部分离的19群肺炎链球菌的耐药性变化  

Antibiotic resistance of serogroup 19 streptococcus pneumoniae isolated from children in Beijing Children's Hospital from 2000 to 2005

作　　者：高薇[1] 姚开虎[1] 俞桑洁[1] 杨永弘[1] 

机构地区：[1]首都医科大学附属北京儿童医院,100045

出　　处：《北京医学》2009年第1期7-11,共5页Beijing Medical Journal

基　　金：国家自然科学基金项目(30070793);"十五"攻关项目(2004BA702A09-01)

摘　　要：目的明确2000-2005年分离的北京儿童19群肺炎链球菌的抗生素敏感性分布及年代变化特点。方法采用简易棋盘式肺炎链球菌分型系统以荚膜肿胀试验进行血清分型。E-test法检测分离株对青霉素等6种抗生素的最低抑菌浓度(minimum inhibitory concentrations,MIC)。结果2002-2003年和2004-2005年肺炎链球菌19群在分离的青霉素不敏感肺炎链球菌中所占比例明显升高,青霉素、头孢克洛和头孢呋辛钠敏感率明显下降,MIC50、MIC90和最大MIC值的水平升高。从MIC值分布看,19群分离株对阿莫西林/克拉维酸和头孢曲松的敏感性下降,但仍处于判定标准的敏感范围。结论2000-2005年自北京儿童医院门诊患儿鼻咽部分离的肺炎链球菌19群对β内酰胺类抗生素耐药性增强,耐药株增多。Objective To investigate the antimicrobial resistance characters of serogroup 19 Streptococcus pneumoniae （S. pneumoniae） isolated from children in Beijing from 2000 to 2005. Methods The serogroup the pneumococcal isolates were determined by the Quellung reaction using simplified chessboard system. The minimum inhibitory concentrations （MIC） was determinated by E - test method for penicillin, amoxicillin/clavulanic acid, cefaclor, cefuroxime, ceftriaxone,and erythromycin. Results The rate of serogroup 19 among S. pneumoniae isolates in 2002 - 2003 and 2004 - 2005 increased significantly compared to that in 2000 - 2001. The susceptibility rates to penicillin, cefaclor and cefuroxime sodium decreased significantly. The values of MIC50,MICg0 and the maximum value of MIC increased for the three antibiotics. The susceptibility to amoxicillin/clavulanic acid and ceftriaxone decreased according to the MICs distribution,but they were still in the susceptibility range estimated by interpretive standard. Conclusions The increased serogroup 19 of S. pneumoniae isolates from children in Beijing are more potent resistant to β- lactam antibiotics.

关 键 词：儿童 肺炎链球菌 抗生素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]