硝基苯对鸭免疫器官及禽流感免疫应答的影响  

Effect of Nitrobenzene Toxication on Immune Organs and Function in Avian Influenza Immune Response in Duck

作　　者：吕树文[1] 孙刚 张加勇 刘娣[3,4] 

机构地区：[1]大庆石油管理局供水公司,黑龙江大庆163451 [2]黑龙江省动物卫生监督所,黑龙江哈尔滨150090 [3]东北林业大学博士后流动站 [4]黑龙江省农业科学院博士后工作站,黑龙江哈尔滨150086

出　　处：《黑龙江农业科学》2009年第1期110-112,共3页Heilongjiang Agricultural Sciences

摘　　要：为探讨硝基苯对鸭免疫器官及免疫应答的影响,以鸭为试验动物,按53.66 mg.kg-1灌胃硝基苯,复制鸭硝基苯中毒及模型。结果表明:(1)硝基苯对免疫器官发育及体液免疫功能造成广泛的抑制效应。(2)硝基苯影响了禽流感抗体的产生,并在较低的水平上维持。(3)硝基苯中毒组胸腺、脾脏、法氏囊脏器指数均低于对照组,(4)硝基苯中毒组鸭胸腺、脾脏、法氏囊出现广泛实质性变化,包括淋巴细胞数量显著减少、变性、坏死、滤泡减少或无滤泡形成,胸腺皮质萎缩。In this paper, ducks were allocated into two groups, the ducks in the contrast group were only fed with the basic diet,the poisoning group was fed with the diet supplemented with 53.66 mg · kg^-1 nitrobenzene. Ducks of the poisoning group showed ducks signs of nitrobenzene toxication. Ducks toxicology model caused by subchronic nitrobenzene toxication was deeply studied trough clinical findings, pathohistological changes, the ELISA of AI and the measurement of thymus, spleen and bursa of FAB. The result showed （1）From organizing pathology, clinical symptom index to observation, nitrobenzene toxication has caused the extensive restrain effect to immune organ development and immune function. （2） Nitrobenzene toxication has influenced the production of the antibody seriously,and kept on the relatively low level. The reducing of the antibody ELISA result titer of AI proved that the immune function received the obvious injury at the same time （3）Thymus,spleen and brusal in group nitrobenzene toxication organs indexes were lower than those of the contrast group. It proved that the nitrobenzene would suppress the growing of immune organ seriously. （4）Immtme organ in histology was observed,including lymphocyte reduce notably by quantity, necrosis,straining and steep strainedding and steep forming.

关 键 词：鸭 硝基苯 免疫器官 禽流感 免疫应答 

分 类 号：S858.32[农业科学—临床兽医学]