南海红树林内生真菌ZSUH36次级代谢物的分离鉴定  

Secondary Metabolites of Mangrove Endophytic Fungus ZSUH 36 from the South China Sea

作　　者：邵长伦[1,2] 谭倪[2,3] 杨瑞云[2,4] 王长云[1] 佘志刚[2] 林永成[2] 

机构地区：[1]中国海洋大学医药学院,青岛266003 [2]中山大学化学与化学工程学院,广州510275 [3]南华大学化学化工学院,衡阳 [4]广西师范大学化学化工学院,桂林

出　　处：《应用化学》2009年第1期7-10,共4页Chinese Journal of Applied Chemistry

基　　金：国家“八六三”科技攻关计划(2006AA09Z422);国家自然科学基金(40776073,20572136);国家教育部新世纪优秀人才支持计划(NCET-05-0600);中国海洋大学博士启动基金(1404-82421036)资助项目

摘　　要：对采自湛江的红树林内生真菌ZSUH 36的次级代谢产物进行了研究。利用硅胶柱层析法从菌丝体中分离得到5个次级代谢产物,利用IR、MS、NMR等现代波谱分析方法对其结构进行了鉴定。结果表明,化合物1和化合物2为首次从海洋真菌中分离得到的次级代谢产物。初步药理活性显示,化合物5对人体肝癌细胞hepG2显示中等抑制活性,其IC50=3.0×10-5g/mL。The secondary metabolites of fungus ZSUH 36 were first isolated from the mangrove plant sample. Five secondary metabolites were isolated from the mycelium of this strain by means of column chromatography. Their structures were identified by comprehensive spectroscopic methods including IR, MS, NMR. To the best of our knowledge, compound 1 and compound 2 were both isolated from marine fungi for the first time. In the preliminary bioassay, compound 5 shows moderate inhibitory activity on the hepG2 cell line with an IC50 value of 3.0 × 10^-5 g/mL.

关 键 词：红树林 内生真菌 次级代谢产物 抗肿瘤活性 

分 类 号：O629[理学—有机化学]