环糊精与丹参酮IIA包合作用的研究  

A study on inclusion complexes of cyclodextrin with tanshinone IIA

作　　者：樊丽[1] 闫金红[2] 常永龙[2] 杨频[2] 

机构地区：[1]中北大学图书馆,山西太原030051 [2]山西大学分子科学研究所化学生物学与分子工程教育部重点实验室,山西太原030006

出　　处：《化学研究与应用》2009年第1期31-35,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(30470408)

摘　　要：通过荧光光谱方法分别研究了丹参酮IIA在溶液的pH为7.5时与β-CD和γ-CD的包合常数,对客体的包结能力β-CD>γ-CD;并利用热力学方法研究了温度对包合反应的影响,计算了包合过程的熵变、焓变及自由能变化;分子模拟方法进一步证实了该包合物的形成;采用超声波法制备了环糊精与丹参酮IIA的固体包合物,并用红外光谱对固体包合物进行了表征.The inclusion complexes of cyclodextrins （β-CD, γ-CD）with tanshinone IIA were confirmed in solution at pH 7.5 by fluorescence spectra, The formation constants of the complexes had been obtained, and the order of values suggested tanshinone IIA associated more strongly withβ-CD thanγ-CD;The effect of temperature on the reaction was studied through thermodynamics. The change of entropy,enthalpy and free energy of the reaction were calculated. The molecular modeling provided further evidence for the formation of the inclusion complexes. Solid complexes was prepared, IR spectra indicated that complexes had been formed.

关 键 词：环糊精 丹参酮IIA 包合物 荧光光谱 热动力学 分子模拟 

分 类 号：O641.3[理学—物理化学]