5-溴嘧啶衍生物的合成研究  

Study on the Synthesis of 5-Bromopyrimidine Derivatives

作　　者：李刚月[1] 张婕[1] 阎圣刚[1] 蒋山[1] 

机构地区：[1]大连海事大学材料科学与工程系高分子材料研究所,辽宁大连116026

出　　处：《广东化工》2009年第1期18-19,34,共3页Guangdong Chemical Industry

摘　　要：以5-溴-2-氯嘧啶为原料,与各种酚发生取代反应,得到系列5-溴-2-取代氧基嘧啶类化合物。研究了取代基效应(包括电性效应、立体效应及取代基位置)对反应收率的影响,结果表明:取代基的空间位阻对反应收率影响很大。该工艺反应条件温和、反应操作简便、易于实施。5-Bromo-2-substituted-oxo-pyrimidine derivatives were synthesized from 5-bromo-2-chloropyrimidine by the substitution reaction with various phenols. The substituent effects （the electronic effect, steric effect and position of substituted groups） on the benzene ring were investigated. The results showed that the size of substituents was a great effect on the yield of reaction. The process features mild conditions, and facile operation was easy to implement.

关 键 词：5-溴-2-氯嘧啶 合成 5-溴嘧啶衍生物 取代基效应 

分 类 号：O626.13[理学—有机化学] S831.5[理学—化学]