草分枝杆菌对难治性结核性脑膜炎患者外周血T淋巴细胞亚群的影响  

Effect of Utilins on Peripheral T-Lymphocyte Subsets in Refractory Tuberculous Meningitis

作　　者：马爱蕊[1] 杨圣俊 王俊霞[1] 闫纪英[1] 周晓映[1] 李洁 李新霞[1] 

机构地区：[1]河北省胸科医院内科,河北石家庄050041 [2]河北省省医院保健科,河北石家庄050000 [3]河北省省直干休一所医务室,河北石家庄050051

出　　处：《中国药业》2009年第2期24-25,共2页China Pharmaceuticals

摘　　要：目的探讨草分枝杆菌对难治性结核性脑膜炎患者外周血中T淋巴细胞亚群的影响。方法选取2005年4月至2007年9月住院的未经抗结核治疗的难治性结核性脑膜炎患者84例,随机均分为两组。治疗组采用草分枝杆菌+HRZE+氟美松+鞘内注药方案,对照组仅用HRZE+氟美松+鞘内注药方案治疗,用药4周。结果治疗组临床疗效明显优于对照组;与治疗组比较,CD3+及CD4+细胞明显增加,CD8+细胞降低,CD4+/CD8+值显著升高(P<0.01)。结论草分枝杆菌对难治性结脑患者具有细胞免疫调节作用,疗效肯定,副作用小,是理想的抗结核辅助用药。Objective To investigate the effect of utilins on peripheral T-lymphocyte subsets in refractory tuberculous meningitis. Methods 84 inpatients of refractory tuberculous meningitis without antituberculosis treatment in April 2005 to September 2007, 25 females and 59 males, aged 15-78 years, were selected and randomly divided into two groups. The treatment group was given utilins ＋ HRZE ＋ dexam- ethasone ＋ intrathecal injection program, the control group was only given HRZE ＋ dexamethasone ＋ intratheeal injection program. The ther- apeutic courses all were 4 weeks. Results The effect in the treatment group was better than that in the control group. Compared with the treatment group, CD3^＋ and CD4^＋ markedly increased and CD8^＋ decreased, the value of CD4^＋/CD8^＋ obviously increased（P 〈 0. 01）. Conclusion Utllins treating refractory tuberculous meningitis has a role in cellular immune regulation with certain curative effect and less side effects. It is an ideal adjuvant anti- TB drug.

关 键 词：草分枝杆菌 难治性结核性脑膜炎 T淋巴细胞亚群 辅助治疗 

分 类 号：R969.4[医药卫生—药理学] R979.5[医药卫生—药学]