祛风除痹颗粒制备工艺的实验研究  

Study on the preparation technology of qufengchubi granules

作　　者：陈杨芳[1] 王珍[2] 陈师农[3] 田军[3] 

机构地区：[1]安徽中医学院药学院,安徽合肥230031 [2]安徽省药品审评认证中心,安徽合肥230022 [3]安徽省药物研究所安徽省中药研究与开发重点实验室,安徽合肥230022

出　　处：《安徽医药》2009年第1期19-21,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的优选祛风除痹颗粒的最佳制备工艺。方法水提取工艺以干膏得率和芍药苷含量为考察指标,采用正交设计法对其提取工艺条件进行优选。确定了制粒方法。结果水提最佳工艺条件:加8倍量水,煎煮3次,每次1 h。以干浸膏法制粒,干膏和辅料比为3∶7。结论优选出的制备工艺科学合理,适合工业化生产。Aim To optimize the preparation technology of qufengchubi granules. Methods With the content of total paeoniflorin presented in the extract and the rate of dried extracts as the indexes for the water extraction process,orthogonal design was used to optimize the conditions for the extraction process. The method of prepared granulation is determined. Results The optimal process of the water extraction for qufengchubi granules was to add 8 times water, decocting 3 times, 1 hour for each time. The extracts is granulated with the dry method. The ratio of dried extracts to accessory is 3 to 7. Conclusion The method is reasonable, stable, and suitable to industrialized production.

关 键 词：祛风除痹颗粒 提取工艺 正交设计 芍药苷 制备工艺 

分 类 号：TQ461[化学工程—制药化工]