奥美拉唑对急性冠脉综合征患者胃黏膜的保护作用  

Role of peros Omeprazole in protecting gastric mucous membrane in patients with acute coronary syndrome

作　　者：蒋勇[1] 

机构地区：[1]四川省富顺县人民医院内科,四川富顺643200

出　　处：《实用医院临床杂志》2009年第1期38-40,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨奥美拉唑对急性冠脉综合征患者胃黏膜的保护作用。方法207例急性冠脉综合征患者,常规治疗109例(对照组),常规治疗基础上加服奥美拉唑98例(治疗组),观察两组急性糜烂出血性胃炎的发生率。结果治疗组急性糜烂出血性胃炎发生率明显低于对照组,差异有显著性意义(P<0.01)。结论治疗急性冠脉综合征患者,可常规给予口服奥美拉唑防治急性糜烂出血性胃炎。Objective To evaluate the role of per os omeprazole in protecting gastric mucous membrane in patient with acute coronary syndrome（ACS）. Methods A total of 207 patients with ACS were enrolled in two groups. Patients in control group （n = 109） received conventional therapies （aspirin, low-molecular-weight heparin, calcium and Isosorbide Mononitrate）. Omeprazole per os was added in addition to conventional therapies in treatment group （ n = 98 ）. The positive rate of fecal occult blood or dominant upper gastrointestinal hemorrhage, that is, acute erosive-hemorrhagic gastritis, were estimated before and after treatment. Results After treatment, the rate of upper gastrointestinal hemorrhage was significantly lower in treatment group than control one （ P 〈 0. 01 ）. Conclusion Per os omeprazole can be conventionally used to prevent and treat acute erosive-hemorrhagic gastritis in patient with ACS.

关 键 词：奥美拉唑 急性冠脉综合征 急性糜烂出血性胃炎 

分 类 号：R975.6[医药卫生—药品] R573.3[医药卫生—药学]