男性与女性系统性红斑狼疮临床特点比较  

Clinical comparative study of male and female systemic lupus erythematosus

作　　者：聂俊华[1] 向碧英[1] 杨才弟[1] 

机构地区：[1]四川省医学科学院附属医院内一科,四川简阳641400

出　　处：《实用医院临床杂志》2009年第1期49-50,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨不同性别系统性红斑狼疮(SLE)的临床特点,提高对男性SLE的认识。方法对197例SLE患者的一般资料、临床表现与实验室检查结果进行回顾性分析。结果男性患者蝶形红斑、光过敏、口腔溃疡发生率低于女性患者(P<0.05),狼疮肾炎、狼疮肺炎、贫血、脾肿大发生率高于女性患者(P<0.05),血红蛋白、血小板、血补体C3下降较女性患者明显(P<0.01),血沉、尿蛋白、血肌酐及尿素氮测值较女性患者高(P<0.001);两组ANA、抗dsDNA抗体、抗sm抗体阳性率差异无显著性意义(P>0.05)。结论男性SLE患者的临床症状不典型,内脏损害重,应加强对男性SLE患者的研究。Objective To explore the clinical characteristics of different genders of patients with systemic lupus erythematosus （SLE） and further improve the understanding of male SLE. Methods We performed a retrospective study on clinical and laboratory indications of 197 SLE patients in our hospital. Results The incidences of symptoms including butterfly erythema, photosenstivity, dental ulcer were lower in male SLE patients than female ones （ P 〈 0.05 ）. The incidences of lupus nephritis, anaemia, splenomegaly were higher in male SLE patients than female ones （ P 〈 0.05 ）. The counts of thrombocyte descent, hemoglobin, blood platelets, blood complement c3 dropped more evidently in male patients than feminine patients （P 〈 0. 01 }. Erythrocyte sedimentation rate, urine protein, serum ereatinine ,urea nitrogen were higher in male patients than female patients （P 〈 0. 001 ）. There was no significant difference in anti-ANA, anti-dsDNA antibody, anti-sm antibody between male and female patients（P 〉 0. 05）. Conclusion Male SLE patients have atypical clinical manifestations but their internal organs are often heavily damaged, so we should strengthen the further research on male patients with SLE.

关 键 词：红斑狼疮 系统性 男性 女性 临床特点 

分 类 号：R593.241[医药卫生—内科学]