替罗非班对急性ST段抬高心肌梗死直接经皮冠状动脉介入治疗患者TIMI血流和预后的影响  

The Effects of Tirofiban on TIMI Flow and Clinical Prognosis in Patients with STEMI during Primary PCI

作　　者：贾治生[1] 侯淑敏[1] 刘延才[1] 母树清[1] 

机构地区：[1]山东省济南市第五人民医院心内科,山东济南250022

出　　处：《中国临床医学》2008年第6期754-755,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:观察国产替罗非班在急性ST段抬高心梗直接经皮冠状动脉介入治疗(PCI)前后应用对冠脉灌注及临床预后的影响,探讨不同应用时机对疗效影响的差异。方法:选择46例符合直接PCI的急性ST段抬高心梗的患者,随机分为治疗组(n=24)和对照组(n=22),比较两组PCI前后梗死相关动脉(IRA)的心肌梗死溶栓治疗(TIMI)血流分级及住院期间的临床预后。结果:治疗组在术后冠脉TIMI分级、心电图ST段回落、7d后左心室射血分数(LVEF)等方面显著优于对照组,肌钙蛋白Ⅰ(cTnl)峰值、住院天数、住院期间主要心血管事件(MACE)及死亡两组之间无差异。结论:对于急性ST段抬高心梗PCI前应用替罗非班可更有效的改善冠脉血流及临床预后,方法安全。Objective：To evaluate the effect of tirofiban on thombolysis in myocardial infarction （TIMI） flow and clinical prognosis in patients with St segment elevation myocardial infarction（STEMI） before and after primary Percutaneous coronary intervention（PCI）. Methods：Forty-six patients with STEMI who underwent primary PCI were randomly divided into two group of threapy （n = 24） and the control group （n = 22）. TIMI flow, the clinical outcomes were compared before and after primary PCI. Results： Group of therapy was superior to control group in terms of TIMI flow grade,ST segment resolution and ejection fraction at 7 days after PCI, The in hospital major adverse cardiac events（MACE） and death rate, peaks of cTnl were similar between the groups. Conclusion： The application of tirofiban before PCI is associated with superior clinical prognosis compared with the after PCI in patieats with STEMI undergoing primary PCI.

关 键 词：心肌梗死 血管成形术 经腔 经皮冠状动脉 替罗非班 

分 类 号：R542.2[医药卫生—心血管疾病]