环孢素A治疗原发性干燥综合征并难治性血小板减少症  

The Treatment of Refractory Thrombopenia in Primary Sjgren Syndrome by Cyclosporine A

作　　者：陈莉莹[1] 孙华瑜[1] 巫斌[1] 陈梅卿[1] 林庆衍[1] 刘雯[1] 

机构地区：[1]福建医科大学附属厦门市第一医院风湿免疫科,福建厦门361003

出　　处：《中国临床医学》2008年第6期902-903,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨环孢素A(cyclosporine A,CsA)联合肾上腺皮质激素、羟氯喹治疗原发性干燥综合征并难治性血小板减少症的疗效及不良反应。方法:对15例原发性干燥综合征并难治性血小板减少症患者,应用环孢素A5mg·kg-1.d-1联合肾上腺皮质激素、羟氯喹治疗,用药期间定期检查血象、肝肾功能、血压,观察不良反应。结果:与治疗前相比,治疗后血小板计数明显升高(P<0.01),总有效率86.6%,其中显效率33.3%,良效率53.3%,不良反应轻。结论:CsA联合肾上腺皮质激素可作为治疗原发性干燥综合症并难治性血小板减少症一种有效方法,并且在大多数患者其毒副反应轻微,可以耐受。Objeetive：To investigate the effeetivenesses and the adverse effects of Cyclosporine A combining with adrenal cortex hormone and hydroxyehloroquine for refractory thrombopenia in primary Sjoegren syndrome. Methods： We selected fifteen cases patients of refractory thrombopenia in primary Sjoegren syndrome, whom were treated by Cyclosporine A 5 mg·kg^-1 · d^-1 combining with adrenal cortex hormone and Hydroxychloryquine. During the medication period, we checked the hemogram, the hepatic and renal function, blood pressure and the adverse effect regularly. Results： When the treatment was finished, patients＇ blood platelets count elevated signifieantly（P〈0.01 ）, comparing with before treatment, and the total effective rate was 86.6%, in which the significant effective rate was 33.3%, the excellent rate was 53.3%, and the adverse effect was slight. Conclusion：Cyclosporine A combining with adrenal cortex hormone was an effective prescription for the treatment of refractory thrombopenia in primary Sjoegren syndrome, and there was slight toxic side reaction for most patients to endure treatment.

关 键 词：环孢素A 干燥综合征 难治性血小板减少症 

分 类 号：R442.8[医药卫生—诊断学]