狭叶藜芦碱甲对犬血流动力学的影响  

Effect of Stenophylline A on Cardiohemodynamics in Anesthetized Dogs

作　　者：马丽焱[1] 周远鹏[2] 江京俐[1] 於兰[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100094 [2]中国药品生物制品检定所

出　　处：《中草药》1998年第2期105-107,共3页Chinese Traditional and Herbal Drugs

摘　　要：麻醉开胸犬iv1．25、2．5μg／kg狭叶黎芦碱甲（V3）后，平均动脉压、心率、左室收缩压、右室内压最大上升速率及心脏做功均明显降低，5min内最强，并且作用随剂量的增加而加强；对心输出量无明显影响；冠脉血流和脑血流亦无显著改变。小鼠iv的LD50为1．1mg／kg。Effects of stenophylline A(V3), 1. 25 and 2. 5μg/kg,iv on hemodynamics were studied in 6 anesthetized dogs. V3 dose-dependently decreased mean arterial pressure, heart rate, left ventricular systolic pressure,dp/dt max with little influence on cardiac output,coronary and cerebral blood flow. The action appared immediately after administration, reached the highest in 5 min, and lasted 20~40min. There was no tachyphylaxis. The LD50(iv) was about 1.1 mg/kg.

关 键 词：藜芦 血流动力学 降压活性 狭叶藜芦碱甲 中药 

分 类 号：R285.5[医药卫生—中药学]