新型温度敏感性自组装胶束P(NiPAAm-co-DMAA)-co-P(L-Ala)的合成和性能  

Synthesis and Properties of Novel Temperature-sensitive Self-assemble Nanomicelles of P(NiPAAm-co-DMAA)-co-P(L-Ala)

作　　者：王海青[1] 俞玫[1] 鲍军波[1] 宋存先[1] 

机构地区：[1]中国医学科学院北京协和医学院,生物医学工程研究所,天津市生物材料重点实验室,天津300192

出　　处：《高等学校化学学报》2009年第1期212-214,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50673100)资助

摘　　要：通过原子转移自由基聚合(ATRP)合成了一种带有活性—NH2基团的温度敏感性亲水型共聚物P(NiPAAm-co-DMAA),并将其作为引发剂,合成了P(NiPAAm-co-DMAA)-co-P(L-Ala),其分子量分布(PDI)在1.3左右.聚合物通过自组装形成纳米胶束.透射电镜(TEM)结果表明,胶束大小200～300nm,具有明显的核壳结构.共聚物的最低临界溶解温度(LCST)为45.5℃.温度低于LCST时,聚合物溶解形成胶束;高于LCST时,胶束解离,聚合物不溶.聚合物对温度的响应是快速而可逆的.A novel temperature-sensitive amphiphilic copolymer of P（NiPAAm-co-DMAA） with active -NH2 group was synthesized by ATRP, which was used as initiator of amino acid polymerization. The PDI of P（NiPAAm-co-DMAA）-co-P（L-Ala） is about 1.3. This polymer could form temperature-sensitive micelle by self-assembly. The diameter and distribution of micelle were observed by TEM. The results show that the siza of micelle is about 200-300 nm and the micelle has obvious core-shell structure. LCST of copolymer is 45.5 ℃. When temperature is under LCST, the copolymer is soluble and form temperature-sensitive micelle. When temperature is above LCST, the micelle dissociate and copolymer is insoluble. Its response to temperature is quickly and reversible.

关 键 词：温度敏感 自组装胶束 P(NiPAAm—co—DMAA)-co—P(L-Ala) 

分 类 号：O631.3[理学—高分子化学]