中性粒细胞非凋亡性程序化细胞死亡的研究概况  

Overview of studies on the non-apoptotic programmed cell death of neutrophils

作　　者：王伟刚[1] 刘佳佳[1] 

机构地区：[1]泸州医学院免疫学教研室,646000

出　　处：《国际免疫学杂志》2009年第1期12-16,共5页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30371305）

摘　　要：中性粒细胞是机体固有免疫应答的主要效应细胞，也是机体内重要的炎症细胞。中性粒细胞除了凋亡和坏死外，还存在一种非凋亡性程序化细胞死亡形式。该形式具有空泡化，线粒体通透性增大等形态学特征，具有caspase-3、caspase-8非依赖性以及无DNA片段化的生物化学特征。目前尚不知其确切的生物学意义，但它与发育和许多生理／病理现象有关。这些研究成果对于重新认识和定位中性粒细胞程丰化细胞死亡的多样性和复杂性提出了新的思路。Polymorphonuclear neutrophils （PMN） are the main effector cells of innate immune responses and the important inflammactory cells in human body. Recently, research data indicated that there might exist a form of noa-apoptotic programmed cell death in PMN, which resembled neither apoptosis nor necrosis. The morphologic changes of the PMN death are characterized by vacuolization and an increase in mitochondria permeability. The biochemical changes of the PMN death are characterized by caspase-3 and caspase-8-in- dependent, and no DNA fragmentation. This form of non-apoptotic programmed cell death of PMN may be related to ontogeny and some physiologic/pathologic phenomena in humay body, although the exact biological significance of the PMN death remains unclear. These research may provide a new thinking of the variety and complexity of p-ogrammed cell death of PMN.

关 键 词：中性粒细胞 非凋亡程序化细胞死亡 空泡化 DNA片段化 

分 类 号：R3[医药卫生—基础医学]