蓖麻毒素在细胞内逆向转运途径的研究进展  

Advancement of Research about Retrotranslocation of Ricin in Cell

作　　者：廖鹏[1,2] 高宏伟[1] 马青原[1] 刘文森[1] 万家余[1] 刘林娜[1] 

机构地区：[1]军事医学科学院军事兽医研究所生物毒素实验室,吉林长春130062 [2]吉林大学畜牧兽医学院,吉林长春130062

出　　处：《现代生物医学进展》2009年第1期167-170,174,共5页Progress in Modern Biomedicine

摘　　要：蓖麻毒素(Ricin)是一种毒蛋白,能抑制蛋白质合成。近年来被用来合成肿瘤导向药物一免疫毒素,在临床应用中仍具有一定的副作用。研究Ricin在细胞内的逆向转运途径有助于其在临床应用中更加完善。本文就Ricin在细胞内的逆向转运途径作一综述。Ricin is one kind of toxic protein that can inhibit the protein synthesis. In recent years, it is used to synthesize tumor targeted medicine-immunotoxin, which still had certain side effect in clinical practice. So, it is very important to further comprehend the retrotranslocation way of Ricin in cell in order to get better application in clinical practice. The retrotranslocation way of Ricin in cell is reviewed in this article.

关 键 词：蓖麻毒素A链 逆向转运 内吞 免疫毒素 

分 类 号：Q548.1[生物学—生物化学] TQ460.4[化学工程—制药化工]