两种驱虫药对肝片吸虫体内γ-氨基丁酸含量的影响  

EFFECTS OF TWO ANTITREMATODAL AGENTS ON THE LEVEL OF γ_AMINOBUTYRIC ACID IN FASCIOLA HEPATICA

作　　者：江善祥[1] 史晓丽[1] 沈丽琳[1] 

机构地区：[1]南京农业大学动物医学院

出　　处：《畜牧与兽医》1998年第1期12-13,共2页Animal Husbandry & Veterinary Medicine

摘　　要：用ＨＰＬＣ法测定在加了不同浓度硝氯酚和丙硫咪唑的Ｒ氏液中体外培养的肝片吸虫体内γ＿氨基丁酸（ＧＡＢＡ）的含量，结果证实硝氯酚能极显著地降低肝片吸虫体内ＧＡＢＡ含量，丙硫咪唑对肝片吸虫体内ＧＡＢＡ含量无显著性影响，硝氯酚的抗肝片吸虫作用可能与ＧＡＢＡ有关，丙硫咪唑的抗吸虫作用可能与ＧＡＢＡ无关。The levels of γ_aminobutyric in F.hepatica incubated in Rohrbacher solution added different concentrations of niclofolan and albendazole were determined by reverse_phase HPLC by precolumn fluorescence derivalization with θPA_β_ME.The level of GABA in F.hepatica incubated in niclofolan was reduced significantly,the mode of actiond of niclofolan is probably relative to GABA.Incubation of the flukes in albendazole resulted in no significant change in the level of GABA,this result suggested that the mechanism for the fasciolicidal activity of albendazole has no relation with GABA.

关 键 词：肝片吸虫 Γ-氨基丁酸 硝氯酚 丙硫咪唑 

分 类 号：S852.735[农业科学—基础兽医学]