斑马鱼行为学实验在神经科学中的应用  

The Ethology Application of Zebrafish in Neuroscience

作　　者：邹苏琪[1] 殷梧[1] 杨昱鹏[1] 陈林[1] 胡兵[1] 

机构地区：[1]中国科学技术大学生命科学学院神经生物与生物物理研究所,合肥230027

出　　处：《生物化学与生物物理进展》2009年第1期5-12,共8页Progress In Biochemistry and Biophysics

摘　　要：斑马鱼作为新型模式动物的优势正在逐渐被人们所认识,其应用的领域也越来越宽广.斑马鱼在神经生物学中的应用,除了在发育方面比其他模式动物更具优势外,在行为学方面的应用也更加丰富.由于斑马鱼幼体在受精后前两天通体透明,眼睛大小占到大脑体积的二分之一以上,成鱼昼夜节律明显,对光反应强烈,因此斑马鱼在视觉领域应用的优势十分明显.斑马鱼的嗅觉、听觉器官都在体表可见,可以很容易地用行为学实验手段对嗅觉和听觉功能进行检测.斑马鱼习性好动,利用斑马鱼进行运动方面的行为学观察也非常便利.斑马鱼具有群聚习性,在社会生物学研究方面正得到越来越多的关注.斑马鱼行为学是一种比较简单而又有效地分析神经整合功能的方法,并形成了许多相关的实验模型.Zebrafish, as a new model of animal, has been gradually accepted and widely used in biology research due to its special characteristics. Besides its convenience used in development research, the application in ethology is more and more extensively. Because of the transparency before 2 days post-fertilization, the eye size nearly half of the brain and its conspicuous circadian rhythm, zebrafish has been significantly applied in vision research. The organs of olfactory and auditory are both visible on the surface, such structure makes it very easy to detect the olfactory and auditory function by means of behavior experiments. Observation of motion is very convenience as zebrafish＇s propensity is active. It is also used more and more in social biology research. The behavior test of zebrafish is a simple and effective method to analyze the integrative neuronal function in vivo while some experimental models have been established which reviewed as follows.

关 键 词：斑马鱼 行为学 神经科学 

分 类 号：Q6[生物学—生物物理学]