毛囊干细胞研究进展  

The Research Advance of Hair Follicle Stem Cell

作　　者：原璐[1] 王春生[1] 安铁洙[1] 

机构地区：[1]东北林业大学生命科学学院,哈尔滨150040

出　　处：《中国生物工程杂志》2009年第1期75-79,共5页China Biotechnology

基　　金：国家自然科学基金资助项目(30751325;30771538)

摘　　要：毛囊干细胞定位在毛囊隆突部,该部位细胞具有其它成体干细胞的共同特性,即慢周期、未分化、自我更新能力及体外增殖能力强等。CD34,K15,K19和Nestin可能作为毛囊干细胞的表面标记。毛囊干细胞在体外可诱导分化为神经元细胞,神经胶质细胞,角化细胞,平滑肌细胞和黑色素细胞等,而在体内(移植后)可分化为神经元、黑色素细胞等。在毛囊干细胞信号调控中涉及到许多的调控信号,主要包括WNT信号、BMP信号和NFATc1等基因的作用。Hair follicle stem cells located bulge region of hair follicle, had characteristics of all adult stem cells, including slow-cycling, undifferentiated. They also had the abilities of self-renew and proliferation in vitro. CD34, K15, K19 and Nestin might be the makers of the hair follicle stem ceils. They could be induced to differentiate to neurons, glial ceils, keratinocytes, smooth muscle cells , melanocytes In vitro and neurons, melanocytes in vivo. There were many signals in regulating the hair follicle stem cells involved Wnt signal, BM Psignal and NFATcl etc.

关 键 词：毛囊干细胞 分化潜能 信号调控 

分 类 号：Q2[生物学—细胞生物学]