周围动脉硬化性疾病与脑卒中及冠心病的相关性  

The relationship between peripheral arterial disease and coronary artery disease and stroke in arterialsclerosis

作　　者：张煜亚[1] 吴庆华[1] 寇镭[1] 罗小云[1] 陈忠[1] 周晗[1] 杨培[1] 

机构地区：[1]北京首都医科大学附属北京安贞医院血管外科,100029

出　　处：《中华医学杂志》2009年第1期29-32,共4页National Medical Journal of China

摘　　要：目的探讨我国周围动脉性疾病（PAD）与冠心病和脑卒中的相关性。同时调查在下肢缺血的周围动脉性疾病患者中凉、麻、疼痛及间歇跛行等症状的发生率及其与踝臂指数（ABI）下降程度的关系。方法前瞻性地对2006年3月至2007年12月心脏科、神经科和血管科患者进行统一ABI测量并记录病史、射血分数、冠状动脉造影和颈动脉超声结果，统计ABI与观察指标的相关性。对PAD患者记录其凉、麻、痛、间歇跛性行和溃疡等症状的程度，并统计各种症状的发生率及其与ABI的相关性。结果心脏科132例患者中，ABI〈0．9的发生率为29．5％，神经科124例患者中，ABI〈0．9的总发生率为17．7％。随着ABI的降低，射血分数逐渐降低，冠状动脉和颈动脉病变程度也逐渐加重。在血管科患者中，ABI均值越低，凉、麻、痛、间歇跛行的程度越重，各种症状为重度时ABI的值大致都在0．4左右。结论29．5％的的冠心病和17．7％的脑卒中患者合并PAD，患者中7．2％的人同时患有这3种疾病。PAD的严重程度与冠心病和脑卒中的严重程度相关。在PAD患者中，随着ABI的降低，肢体缺血症状逐渐加重，当ABI〈0．40时各种症状显著加剧。Objective The purpose of the study was to investigate the relationship between peripheral arterial disease （PAD）and coronary artery disease or stroke in Chinese. At the same time, investigate the prevalence of symptoms, include cold, numb, pain, intermittent claudication and ulcer, then investigate the relationship between abnormal ABI and them. Methods Hospitalized patients in department of cardiology , neurology and vascular were enrolled from March 2006 to December 2007 consecutively. ABI was measured and the disease history was collected. Ejective Fraction （EF）, cardioangiography of coronary artery, and ultrasound examination of cervical artery were recorded too to analyze the relationship between them and ABI. The degree of cold, numb, pain, intermittent claudication and ulcer were recorded in patients with PAD, to analyze the relationship between the prevalence and ABI. Results In 132 patients of department of cardiology, the prevalence of ABI 〈 0. 9 was 29. 5%, In 124 patients of department of neurology, the prevalence of ABI 〈0.9 was 17. 7%. When ABI decreased, the EF decreased too, and the disease of coronary artery and cervical artery became more serious. In patients of vascular department, when ABI decreased , the symptoms of cold, numb, pain, intermittent claudication and ulcer aggravated. Conclusions In Chinese, in patients with coronary artery disease , the prevalence of PAD is 29. 5%, and in patients with stroke the prevalence of PAD is 17.7%. 7.2% patients have these three disease. PAD has relationship with the severity of these two diseases. In patients with PAD, the symptoms will aggravate when ABI decreased. When ABI 〈 0.4, the symptoms all aggravate significantly.

关 键 词：踝臂指数 外周动脉病 心血管疾病 危险因素 

分 类 号：R686[医药卫生—骨科学]