Ⅱ型糖尿病与子宫内膜癌发生的危险性分析  

Risk analysis on type Ⅱ diabetes mellitus patients complicating endometrioid carcinoma

作　　者：梁远[1] 滕家安[1] 秦俭[1] 王仁生[1] 汤春园[1] 

机构地区：[1]广西壮族自治区卫生厅医政处,广西南宁530021

出　　处：《中华肿瘤防治杂志》2008年第19期1448-1450,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：广西卫生厅自筹经费项目(z2007103)

摘　　要：目的:探讨Ⅱ型糖尿病(T2DM)是否为子宫内膜癌(EC)发生发展中的重要危险因素。方法:采用病例对照研究的方法对462例EC患者T2DM合并状况及相关危险因素进行调查分析。结果:43.7%EC患者的发病年龄在50～59岁;T2DM患EC的危险性显著高于非T2DM患者,相对危险度(OR值)为2.402;有糖尿病家族史和(或)EC家族史者发生EC的危险性明显高于无糖尿病或EC家族史者,其OR值分别为4.423和4.536;EC发生的危险性与T2DM病程的长短可能无关;EC合并T2DM患者发生局部淋巴结或远处转移的危险性高于未合并T2DM者,OR值为3.387。结论:糖尿病和(或)EC家族史与T2DM在EC的发生中有协同作用,对这一高危人群中定期进行妇科检查可能早发现、早诊断EC。合并T2DM的EC患者发生肿瘤局部和远处转移的可能性增高。OBJECTIVE： To investigate the relationship between type 2 diabetes mellitus（T2DM） and endometrioid carcinoma（EC） in women. METHODS： Case-control study was adopted to investigate the condition of T2DM and correlated risk factors of 462 EC patients. RESULTS： 43.7% EC patients were in 50 59 years old group. The risk of EC increased in patients with T2DM than that in patients without T2DM, and the relative risk （OR） was 2. 402. The risk of EC was higher in T2DM patients with DM and EC family history patients than that in T2DM patients without falily history, and the OR were 4. 423 and 4. 536 respectively. The risk of EC might not related with the T2DM course. The risk of metastasis of lymph node or other organs increased in T2DM patients complicated with EC than that in EC patients without T2DM, and the OR was 3. 387. CONCLUSION： T2DM and EC family history have synergistic effect with T2DM on EC. The EC patients with T2DM have liability to metastasis of lymph note or distant metastasis.

关 键 词：糖尿病 2型 子宫内膜肿瘤 危险因素 

分 类 号：R587.1[医药卫生—内分泌] R737.33[医药卫生—内科学]