人参总皂苷渗透泵片制备及体外释放度考察  

Preparation of Gensenosides Microbore Osmotic Pump Tablet and Investigation of Release in vitro

作　　者：李肖屹[1] 尹蓉莉[1] 钟玲[2] 李君富[1] 罗燕[1] 

机构地区：[1]成都中医药大学,611130 [2]成都医学院

出　　处：《医学研究杂志》2009年第1期66-68,共3页Journal of Medical Research

摘　　要：目的制备人参总皂苷微孔渗透泵片,考察该制剂的体外释放度。方法制备人参总皂苷微孔渗透泵片,根据不同时间累计释放度考察药物的释放。结果制备了人参总皂苷微孔渗透泵片,并考察了该制剂的体外释放度,绘制释放曲线。结论人参总皂苷微孔渗透泵片的体外释药行为基本符合零级释放规律,该制剂在10h内可达到渗透泵控释给药的效果。Objective To prepare gensenosides mierobore osmotic pump tablet, and to investigate releasing in vitro. Methods We pre- pared gensenosides microbore osmotic pump tablet to investigate the release in vitro by cumulative release rate in different time. Results We prepared gensenosides microbore osmotic pump tablet successfully and investigated releasing in vitro and drew the release curve. Conclusion The release of gensenosides rnicrobore osmotic pump tablet in vitro consists with zero order release rule. It can chalk the effect in ten hours.

关 键 词：人参总皂苷 微孔渗透泵片 体外释放度 

分 类 号：R971.1[医药卫生—药品] R94[医药卫生—药学]