精氨酸强化的全肠外营养在外科营养支持中的应用  

Application of Arginine-enriched Total Parenteral Nutrition in Surgical Nutrition Support

作　　者：黄义昆[1] 夏涛[1] 李威[1] 秦荣新[1] 梁建成[1] 刘百义[1] 

机构地区：[1]广西医科大学第五附属医院,柳州市545001

出　　处：《中国药房》2009年第2期125-127,共3页China Pharmacy

基　　金：广西柳州市科技攻关项目(20020231)

摘　　要：目的:研究腹部手术后使用精氨酸强化的全肠外营养(TPN)对患者营养及免疫状况的影响。方法:选择67例接受腹部手术和TPN的患者,随机分为对照组(常规TPN支持,24例)、试验Ⅰ组(TPN+15g精氨酸,25例)和试验Ⅱ组(TPN+30g精氨酸,18例),术后连续应用3d。结果:精氨酸强化的TPN提高了术后氮平衡的水平,促进血浆白蛋白、总蛋白的恢复,并使CD4+、CD4+/CD8+升高。在观察的周期内对免疫球蛋白和补体C3、C4的影响没有显著性意义。结论:精氨酸强化的TPN能提高术后患者的营养和免疫指标,提高TPN支持的效果。OBJECTIVE： To evaluate the effects of arginine - enriched total parenteral nutrition （TPN） on the nutritional and immune parameters of patients undergoing abdominal surgery. METHODS： 67 patients undergoing abdominal surgery were randomly assigned to receive routine TPN （control group, n = 24）, TPN plus 15 g arginine （n = 25, trial group Ⅰ ） or TPN plus 30 g arginine（n = 18, trial group Ⅱ） for 3 days postoperatively. RESULTS： Arginene-enriched TPN significantly improved postoperative nitrogen balance, promoted the recovery of plasma-albumin and total protein, and elevated the levels of CD4 ^＋ and CD4^＋/ CD8 ^＋, but no significant difference was noted for immunoglobulin, complement Ca and complement C4 during trial period. CONCLUSION： Arginene enriched TPN can improve patients＇ postoperative nutritional and immune parameters and enhance the efficacy of TPN support.

关 键 词：全肠外营养 精氨酸 氮平衡 免疫 

分 类 号：R977.4[医药卫生—药品] R982[医药卫生—药学]