阿仑膦酸钠在鲁米诺-过氧化氢-铜离子体系中的化学发光分析  

Determination of Alendronate Sodium with Luminol-H_2O_2-Cu^(2+) System by Chemiluminescence

作　　者：安普丽[1] 赵静[2] 蒋晔[1] 

机构地区：[1]河北医科大学药学院分析化学教研室,河北石家庄050017 [2]沧州市中心医院制剂科,河北沧州061000

出　　处：《中国医药工业杂志》2009年第1期48-51,共4页Chinese Journal of Pharmaceuticals

基　　金：河北省自然科学基金项目(C2007000792)

摘　　要：根据阿仑膦酸钠(1)在碱性条件下对鲁米诺-过氧化氢-铜离子体系有增敏作用,建立了流动注射-化学发光法测定1。在1.25～50μg/ml浓度范围内它与发光信号的增加值(△I)呈良好的线性关系,检出限为0.41μg/ml,平均回收率为100.6%,RSD小于2.2%。Based on the sensitization behavior of alendronate sodium on the chemiluminescence reaction of luminol-H2O2-Cu^2＋ in basic medium, a flow injection method was established. Alendronate sodium was linear with the enhancement of chemiluminescence emission intensity in the concentration range of 1.25 - 50μg/ml. The detection limit was 0.41 μg/ml. The average recovery was 100.6 % with RSD less than 2.2 %.

关 键 词：阿仑膦酸钠 流动注射 化学发光 鲁米诺 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.32[化学工程—制药化工]