低剂量纳洛酮对布托啡诺镇痛效应的影响  

The effect of low dose naloxone on analgesia of butorphanol

作　　者：刘毅[1] 刘婷[1] 么继钢[1] 刘亮[1] 何珂[2] 卓九五[3] 戴体俊[4] 

机构地区：[1]徐州医学院麻醉学院 [2]徐州医学院临床医学一系 [3]徐州医学院华方学院 [4]徐州医学院麻醉药理学教研室,徐州221002

出　　处：《世界临床药物》2009年第1期27-29,共3页World Clinical Drug

基　　金：国家自然科学基金资助项目(30471657;39970715);江苏省自然科学基金资助项目(BK200143);2007年江苏省高等学校大学生实践创新训练计划项目(404)

摘　　要：目的观察低剂量纳洛酮(naloxone)对布托啡诺(butorphanol)镇痛效应的影响。方法受试小鼠80只随机分为2组,分别接受扭体法(40只,雌雄各半)和热板法(40只,雌性)试验,观察纳洛酮对布托啡诺镇痛小鼠热板法痛阈(HPPT)和扭体次数的影响。各组再按分层随机设计分为BS组(镇痛剂量布托啡诺与生理盐水合用)、BN1组、BN2组和BN3组(布托啡诺分别与纳洛酮100、10、1ng/kg合用)。结果热板法试验提示,与BS组比较,BN2组HPPT在用药后20、30min均增大(P<0.05);扭体法试验提示,与BS组比较,BN2组扭体次数减少(P<0.05)。结论低剂量纳洛酮可增强布托啡诺的镇痛效应,且以纳洛酮10ng/kg效果最好。Objective To observe the effect of low dose naloxone on analgesia ofbutorphanol. Methods 80 Kunming Jimpy mice were divided into 2 groups. 40 accepted hot-plate method and another 40 accepted stretching method. Each group was randomly divided into 4 groups furtherly： Group BS （butorphanol combined with sodium chloride） and group BN1, group BN2, group BN3 （butorphanol combined with naloxone 100 ng/kg, 10 ng/kg and 1 ng/kg respectively）. Pain threshold in hot-plate test （HPPT） and the number of stretching times were observed. Results Compared with group BS, HPPT of Jimpy mice in group BN2 increased significantly at 20 and 30 min （P 〈 0.05 ） and the number of stretching times of Jimpy mice in group BN2 reduced significantly （P 〈 0.05）. Conclusion Low dose naloxone can enhance the analgesic effect of butorphanol, and the dose of 10 ng/kg has the best effect.

关 键 词：纳洛酮 布托啡诺 镇痛 联合用药 

分 类 号：R971.2[医药卫生—药品]