Functional Analyses of Mammalian Reovirus Nonstructural Protein μNS  

作　　者：Chao FAN Qin FANG 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Virologica Sinica》2009年第1期1-8,共8页中国病毒学（英文版）

基　　金：National Basic Research Program of China (973 Program) ( 2009CB118701);National Natural Scientific Foundation of China (30671615, 30871940);Innovation project of the Chinese Academy of Sciences(KSCX2-YW-N-021 to QF).

摘　　要：Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein uNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that uNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein μNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that μNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.

关 键 词：dsRNA virus Mammalian orthoreoviruses Nonstructural protein uNS 

分 类 号：S852.659.4[农业科学—基础兽医学] Q78[农业科学—兽医学]