米索前列醇联合缩宫素预防产后出血360例临床观察  

Clinical observation of the effect of misoprostol combined with oxytocin in preventing postpartum hemorrhage

作　　者：杨武红[1] 汪建一[2] 

机构地区：[1]安县人民医院,四川安县622651 [2]四川中医药高等专科学校,四川绵阳621000

出　　处：《现代医药卫生》2009年第2期171-173,共3页Journal of Modern Medicine & Health

摘　　要：目的:观察米索前列醇联合缩宫素预防产后出血的临床效果。方法:选择360例产妇,随机分为试验组200例与对照组160例。试验组在胎儿娩出后立即给予米索前列醇0.2 mg塞肛并同时用缩宫素20 U静脉注射。对照组在胎儿娩出后只用缩宫素20U静脉注射。观察两组产妇第三产程时间、产后2 h及产后24 h的出血量及不良反应。结果:两组产妇第三产程时间相比,试验组较对照组短,差异有显著性(P<0.05),产后2 h出血量、产后24 h出血量、产后出血发生率相比,试验组均较对照组低,差异有显著性(P<0.05),试验组出现发热、寒战8例,恶心5例,对照组未出现上述不良反应,两组产妇用药前后血压,脉搏无明显变化。结论:米索前列醇联合缩宫素对缩短第三产程时间,减少产后出血量,预防产后出血效果明显,不良反应小,值得在临床上推广。Objective ：To investigate the chnical observation of the effect of misoprostol combined with oxytocin in preventing postpartum hemorrhage.Methods：360 patients who had the risk of postpartum hemorrhage were randomly divided into two groups：200 patients in test group and 160 patients in control group. The test group was given 0.2 mg misoprostol per rectum and 20 U oxytocin by iv immediately after labor,the control group was given 20 U oxytocin by iv after labor. The following items in the 2 groups such as time of the third stage of labor, hemorrhage amount of 2h and 24h after labor, the incidence of postpartum hemorrhage and side effects were observed.Results：The time of the third stage of labor of the test group was shortter than that of the control group,the difference was significant（P〈0.05）.The hemorrhage amount of 2h and 24h,the incidence of postpartum hemorrhage in the test group were lower than those in the control group, the difference was significant （P〈0.05）.Conclusion：Misoprostol combined with oxytocin has good effect in shortening time of the third stage of labor, decreasing postpartum hemorrhage amount and preventing postpartum hemorrhage, with less side effects, it＇s worth clinically spreading.

关 键 词：米索前列醇 缩宫素 产后出血 预防 

分 类 号：R71[医药卫生—妇产科学]