加替沙星引起血糖紊乱的可能机制  

Mechanisms of Gatifloxacin-induced Glucose Homeostasis Abnormalities

作　　者：李峰[1] 李杨[1] 庄毅超[1] 钮晓淑[1] 刘晓东[1] 

机构地区：[1]中国药科大学药物代谢动力学重点实验室,江苏南京210009

出　　处：《药学进展》2009年第1期14-17,共4页Progress in Pharmaceutical Sciences

基　　金：国家基础科学人才培养基金(No.J0630858)

摘　　要：对抗菌药加替沙星引起用药者血糖紊乱的可能机制进行了分析和讨论,如干扰某些与血糖相关的内源性物质(胰岛素、肾上腺素、组胺等)的释放、影响葡萄糖转运体1的表达与功能、抑制机体糖异生途径等,以供从事临床工作和药物研发的人士参考。The mechanisms of blood glucose disorders induced by gatifloxacin were discussed, which include disturbing glucose homeostasis via regulating the release of endogenous substance （such as insulin, epinephrine, histamine, etc）, impacting GLUT1 gene expression and inhibiting gluconeogenesis, so as to provide a reference for research and development personnel and clinicians.

关 键 词：加替沙星 血糖紊乱 不良反应 作用机制 

分 类 号：R96[医药卫生—药理学]