多甘醇-磷酸酯-EDTA酯共聚物铁(Ⅲ)配合物的合成和磁共振成象增强作用  

SYNTHESIS AND MRI ENHANCEMENT OF IRON(Ⅲ) COMPLEXES WITH PHOSPHATE- EDTA-POLYGLYCOL TERPOLYMER LIGANDS

作　　者：俞开潮[1,2] 冯继文[1,2] 胡红兵[1,2] 卢广 卓仁禧[1,2] 李丽云 叶朝辉 

机构地区：[1]中国科学院武汉物理与数学研究所 [2]武汉大学化学学院

出　　处：《波谱学杂志》1998年第2期123-130,144,共9页Chinese Journal of Magnetic Resonance

基　　金：波谱与原子分子物理国家重点实验室基金

摘　　要：通过乙二胺四乙酸双酸酐、二氯磷酸酯与多甘醇共缩聚，制得一系列三元共聚物配体．用配体与三氯化铁反应，得到相应的铁配合物．表征了配体和配合物的化学结构，测试了配合物的纵向弛豫速率，并考察了配合物的急性毒性和磁共振成象增强作用．A new series of polyglycol-phosphate-EDTA ester terpolymer ligands were synthesized by the copolymerization of ethylene diamine tetraacetic dianhydride(EDTAA),ethyl phosphodichloridate (or methyl phosphodichloridate, n-butyl phosphodichloridate) with diethylene glycol or triethylene glycol,and their Fe(Ⅲ) complexes were prepared. The structures of these new ligands and Fe(Ⅲ) complexes were comfirmed by 1 H NMR,IR and elemental analysis. The longitudinal relaxation measurements on these macromolecular complexes indicated that most of them have higher relaxivity as compared to Fe(Ⅲ) EDTA.Moreover,the acute toxicity test using one of these Fe(Ⅲ) complexes was performed and no obvious toxicity was observed.Finally,T 1 weighted contrast imaging of rat liver showed clear MRI enhancement after injection the new complex.

关 键 词：磁共振成 铁配合物 影象诊断 大分子造影剂 

分 类 号：R445.2[医药卫生—影像医学与核医学] R981[医药卫生—诊断学]