Facile and Convenient One-pot Synthesis of 1,1-Disubstituted Cyclopropanes in Water  

作　　者：LIU Chun PAN Wei YANG Yang WANG Ke-wei DONG De-wen 

机构地区：[1]Chemistry and Biology College, Beihua University, Jilin 132013, P. R. China [2]Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China

出　　处：《Chemical Research in Chinese Universities》2009年第1期37-39,共3页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.20572013, 20711130229);the Ministry of Educa-tion of China(No.105061).

摘　　要：A facile and convenient one-pot synthesis method of substituted cyclopropanes in water has been developed. A series of 1,1-disubstituted cyclopropanes 3 were synthesized from the reaction of β-dicarbonyl compounds 1 with 1,2-dibromoethane 2, in very high yields catalyzed by tetrabutylammonium bromide（TBAB） at 50 ℃ in the presence of K2CO3 in water. The catalyst TBAB in the aqueous phase can be reused after the separation of organic products.A facile and convenient one-pot synthesis method of substituted cyclopropanes in water has been developed. A series of 1,1-disubstituted cyclopropanes 3 were synthesized from the reaction of β-dicarbonyl compounds 1 with 1,2-dibromoethane 2, in very high yields catalyzed by tetrabutylammonium bromide（TBAB） at 50 ℃ in the presence of K2CO3 in water. The catalyst TBAB in the aqueous phase can be reused after the separation of organic products.

关 键 词：CYCLOPROPANE β-Dicarbonyl compound Tetrabutylammonium bromide WATER 

分 类 号：O623.1[理学—有机化学]