毛鱼藤根中的鱼藤酮类化合物Ⅱ(英文)  

Rotenoids from the Root of Derris elliptica (Roxb.) Benth. Ⅱ

作　　者：卢海英[1] 梁敬钰[1] 余平[1] 陈雪英[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210009

出　　处：《中国天然药物》2009年第1期24-27,共4页

基　　金：supported by the Research Foundation of Ph D Program in Universities, Ministry of Education of China (No20070316003)~~

摘　　要：目的:对广东产毛鱼藤(Derris elliptica (Roxb.) Benth.)根的化学成分进行研究。方法:运用多种层析手段进行分离纯化, 通过波谱解析和理化鉴别进行结构鉴定。结果:分离鉴定了7个鱼藤酮类化合物, 分别为:7′-羟基-6a, 12a-脱氢鱼藤素(7′-hydroxy-6a, 12a-dehydrodeguelin, 1), 6-羟基-6a, 12a-脱氢鱼藤素(6-hydroxy-6a, 12a- dehydrodeguelin, 2), (6aR, 12aR, 4′R, 5′S)-4′, 5′-dihydro-4′, 5′-dihydroxytephrosin (3), 6′-羟基-6a, 12a-脱氢鱼藤酮(6′-hydroxy-6a, 12a-dehydrorotenone, 4), (-)-rotoic acid (5), (-)-deguoic acid(6), 12-deoxo-12α-acetoxyelliptone(7)。结论:化合物1为新化合物, 化合物2～ 6为首次从鱼藤属中分得, 化合物7为首次从毛鱼藤中分得。AIM： To study the chemical constituents of Derris elliptica （Roxb.） Benth. METHOD： The chemical constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analysis. RESULTS： Seven rotenoids were obtained and their structures were identified as 7＂-hydroxy-6a, 12a-dehydrodeguelin （1）, 6-hydroxy-6a, 12a-dehydrodegnelin （2）, （6aR, 12aR, 4＂R, 5＂S）-4＂, 5＂-dihydro-4＂, 5＂-dihydroxytephrosin （3）, 6＂-hydroxy-6a, 12a- dehydrorotenone （4）, （-）-rotoic acid （5）, （-）-degnoic acid （6）, 12-deoxo-12a-acetoxyelliptone （7）. CONCLUSION： Compound 1 is a new compound, compounds 2-6 were isolated from this genus for the first time, and compound 7 was isolated from Derris eUiptica （Roxb.） Benth. for the first time.

关 键 词：毛鱼藤 鱼藤属 鱼藤酮类化合物 7'-羟基-6a 12a-脱氢鱼藤素 

分 类 号：R284.1[医药卫生—中药学]