凹叶瑞香中的香豆素成分(英文)  

Coumarins from Daphne retusa

作　　者：扈晓佳[1] 金慧子[1] 苏娟[2] 张薇[2] 许文争[1] 严诗凯[1] 柳润辉[2] 李建强 张卫东[1,2] 

机构地区：[1]上海交通大学药学院,上海200240 [2]上海第二军医大学药学院,上海200433 [3]河南洛阳栾川林业科学研究所,栾川417500

出　　处：《中国天然药物》2009年第1期34-36,共3页

基　　金：supported by the Scientific and Technology Commission Foundation for Modernization of Traditional Chinese Medicine of Shanghai China (No 05DZ19733)~~

摘　　要：目的:对凹叶瑞香(Daphne retusa)的化学成分进行研究。方法:利用硅胶柱色谱,Sephadex LH-20和RP18反相柱色谱的方法分离和纯化化合物,通过光谱方法及理化性质鉴定化合物结构。结果:从凹叶瑞香氯仿部位分离得到8个香豆素类成分,分别为7-羟基香豆素(1),7-甲氧基-8-羟基香豆素(2),7-羟基-8-甲氧基香豆素(3),双白瑞香素-7-O-β-D-葡萄糖苷(4),伞形花内酯-7-O-β-D-葡萄糖苷(5),结香苷A和C(6和7),[8,8'-bi-2H-1-benzopyran]-2,2'-dione,7'-(α-D-glu-copyranosyloxy)-7-hydroxy-3-[(2-oxo-2H-1-benzopyran-7-yl)oxy](8)。结论:所有化合物均为首次从该植物中分得。AIM： To study the chemical constituents on the stems and barks of Daphne retusa. METHODS： Compounds were separated by column chromatography with silica gel, Sephadex LH-20 and RP18 silica gel. Their structures were elucidated on the basis of physiochemical and spectral analyses. RESULTS： Eight compounds were isolated from D. retusa, and their structures were identified as 7-hydroxycoumarin （1）, 7-methoxy-8-hydroxycoumarin （2）, 7-hydroxy-8-methoxycoumarin （3）, daphnoretin-7-O-β-D-glucoside （4）, umbeliferone-7-O-β-D-glucoside （5）, edgeworside A and C （6 and 7）, and [8,8＇-bi-2H-1- benzopyran]-2, 2＇-dione, 7＇-（α-D-glucopyranosyloxy）-7-hydroxyl-3-[（2-oxo-2H-1-benzopyran-7-yl）oxy] （8）. CONCLUSION： Compounds 1 - 8 have been isolated from this plant for the first time.

关 键 词：凹叶瑞香 瑞香科 香豆素 

分 类 号：R284.1[医药卫生—中药学]