慢性乙型肝炎急性发作后患者体液免疫动态变化的研究  

Dynamic Changes of Humoral Immunity after Acute Episode in Patients with Chronic Hepatitis B

作　　者：谷军生[1] 余祖江[1] 江河清[1] 

机构地区：[1]郑州大学第一附属医院感染科,郑州市450052

出　　处：《医药论坛杂志》2009年第1期5-7,共3页Journal of Medical Forum

摘　　要：目的动态观察慢性乙型肝炎患者急性发作后血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和血清免疫球蛋白G(IgG)等指标,探讨慢性乙型肝炎急性发作后宿主肝功能损伤和体液免疫动态变化间的关系。方法随机选取16例HBc-IgM阳性慢性乙型肝炎患者为实验组,16例HBc-IgM阴性者为对照组,分别检测其血清ALT、AST和IgG,31(30.80±12.60)d后第二次检测HBc-IgM阳性组患者的上述指标。结果①HBc-IgM阳性组患者血清ALT、AST和IgG均高于HBc-IgM阴性组,两组间有显著性差异(P<0.05)。②HBc-IgM阳性患者血清ALT和AST第一次测定结果高于第二次,两组间有显著性差异(P<0.05);血清免疫球蛋白G第一次检测结果与第二次相比无显著性差异(P>0.05)。③HBc-IgM阳性组患者血清IgG第二次测定结果高于HBc-IgM阴性组,两组间有显著性差异(P<0.05)。结论慢性乙型肝炎急性发作后,患者血清IgG水平和转氨酶升降一致,血清IgG水平对于判断慢性乙型肝炎患者肝内活动性病变有一定临床意义。Objective Serum ALT,AST sode to observe the relationship between liver tis B. Methods Sixteen chronic hepatitis B and IgG were dynamically detected after acute epidamage and IgG in serum of patients with chronic hepatipatients with positive HBc -IgM were selected randomly into examination group and another sixteen with negative HBc - IgM to contrast group. Serum ALT,AST and IgG of patients were dynamically detected when patients were hospitalized and the repeated detection were taken 31 （30. 80 ± 12.60 ） days later in the examination group. Results ①Mean of serum ALT, AST and IgG of patients in HBc - IgM positive group were higher than those of patients in HBc - IgM negative group. Difference between the two groups reached statistic significance （ P 〈 0. 05）. ② Means of serum ALT,AST of patients in HBc - IgM positive group that were detected when the patients were hospitalized were higher than that detected 31 （30. 80 ± 12. 60）days later. Difference between them reached statistic significance （ P 〈 0.05 ）. There was no significant difference between the two detections of serum IgG in patients with positive HBc -IgM（ P 〉 0. 05 ）. ③Mean of the second detection of serum IgG of patients in HBc - IgM positive group was higher than that of patients in HBc - IgM negative group. Difference between them reached statistic significance （ P 〈 0. 05）. Conclusion Level of serum IgG coincided with that of serum transaminase during acute episode of chronic hepatitisB. Serum IgG is helpful in judging active inflammation process in the liver of patients with chronic hepatitis B.

关 键 词：乙型肝炎 体液免疫 研究 

分 类 号：R512.62[医药卫生—内科学]