血管内皮生长因子和胎盘生长因子在子痫前期及子痫患者胎盘组织中的表达  

Expression of Vascular Endotheliul Growth Factor and Placental Growth Factor in Placenta Tissues of Patients with Preeclampsia and Eclampsia

作　　者：滕红[1] 程春花 邱玲[1] 王改珍[1] 

机构地区：[1]吉林大学第二医院妇产科,长春130042 [2]河南省妇幼保健院妇产科,郑州450052

出　　处：《中国生物制品学杂志》2009年第1期78-80,共3页Chinese Journal of Biologicals

摘　　要：目的检测血管内皮生长因子(VEGF)和胎盘生长因子(PLGF)在子痫前期及子痫患者胎盘组织中的表达,探讨两者与子痫前期和子痫的相关性。方法采用亲和免疫细胞化学技术SABC(链霉素-生物素-过氧化物酶复合物技术)对正常妊娠组、轻度子痫前期组、重度子痫前期组和子痫组(每组各20名孕妇)胎盘组织中的VEGF和PLGF进行检测。结果各组孕妇胎盘组织中的VEGF和PLGF主要分布于滋养叶细胞,其次是蜕膜组织,绒毛血管内皮细胞和部分间质细胞也有表达。轻度和重度子痫前期组胎盘组织中VEGF和PLGF的表达强度明显低于正常妊娠组,重度子痫前期组明显低于轻度子痫前期组,且差异均有统计学意义;子痫组与重度子痫前期组比较,差异无统计学意义。结论VEGF和PLGF在子痫前期及子痫患者胎盘组织中表达的下降可能是其发病的重要因素。Objective To determine the expression levels of vascular endotheliul growth factor （VEGF） and placental growth factor （PLGF） in the placeta tissue of patients with preeclampsia and eclampsia and explore the relationship of VEGF and PLGF to preeclampsia and eclampsia. Methods Determine the expression levels of VEGF and PLGF in the placenta tissues of 20 healthy pregnant women, 20 pregnant women with mild preeclampsia, 20 pregnant women with severe preeclumpsia and 20 pregnant women with eclampsia by streptavidin-biotin-peroxidase complex （ SABC ） technique. Results VEGF and PI,GF were mainly expressed in trophoblast, next in decidua and endothelial cells, and also in stroma. The expression levels of VEGF and PLGF were significantly lower in the placenta tissues of pregnant women with preeclampsia than in those of healthy pregnant women, and significantly lower in pregnant women with severe preeclampsia than in those with mild preeclampsia. However, the expression in the placenta tissues of pregnant women with eclampsia showed no significant difference from those with severe preeclumpsia. Conclusion The decreased expression of VEGF and PLGF in placenta tissues may be an important cause for preeclampsia and eclampsia.

关 键 词：血管内皮生长因子 胎盘生长因子 子痫前期 子痫 

分 类 号：R321.4[医药卫生—人体解剖和组织胚胎学]