加味枇杷清肺颗粒对兔耳痤疮模型抗角化作用及睾酮水平的影响  

Effects of Pipaqingfei Particle Plus on Anti-keratinization and the Level of Testosterone in Rabbit Ear Acne Model

作　　者：徐骅[1] 陈钧[1] 刘炯[1] 徐蓉[1] 

机构地区：[1]江苏大学药学院,江苏镇江212013

出　　处：《中国皮肤性病学杂志》2009年第1期13-15,28,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的观察加味枇杷清肺颗粒对兔耳痤疮模型的治疗效果。方法用5%煤焦油溶液涂抹兔耳造模,成功后随机分组,分别灌胃加味枇杷清肺颗粒、枇杷清肺饮经典方颗粒和珍珠暗疮片2周。通过肉眼和镜下观察抗角化作用,采用放射免疫分析法测定血清睾酮含量。结果造模后,肉眼可见兔耳表面粗糙、增厚、有粉刺样皮损,组织病理改变与人类痤疮相似。灌胃加味枇杷清肺颗粒后,兔耳毛囊角化程度改善,血清睾酮含量降低,并呈量效关系。结论加味枇杷清肺颗粒有抗实验性痤疮的作用。Objective To study the effect of Pipaqingfei particle-plus on acne model in rabbits. Methods 5% Pix carbonis solution was coated to rabbit-ears to build animal model. Then the rabbits were randomly divided into three groups： Pipaqingfei particle-plus groups, classical Pipaqingfei-particle group, and Zhenzhu, Anehuang tabulate group. And then, the anti-keratosis actions of the tested drugs were observed by naked eye and by microscope, and the serum testosterone was measured by radioimmunoassay. Results After coating Pix 2 weeks, the surface of rabbilt-ears became rougher, thicker, and the comedone appeared on rabbit-ears. The pathological charges were similar to that of human ache. After giving Pipaqingfei particle-plus 2 weeks later, the acne keratosis was suppressed and the level of testosterone was decreased, and showed dosage-effect relationship. Conclusion Pipaqingfei particle-plus has anti-ache effects.

关 键 词：痤疮 枇杷清肺饮 抗角化 雄激素 

分 类 号：R758.73[医药卫生—皮肤病学与性病学] R28[医药卫生—临床医学]