Signaling cross-talk between TGF-β/BMP and other pathways  

作　　者：Xing Guo Xiao-Fan Wang 

机构地区：[1]Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA [2]Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA

出　　处：《Cell Research》2009年第1期71-88,共18页细胞研究（英文版）

摘　　要：Transforming growth factor-beta （TGF-β）/bone morphogenic protein （BMP） signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/ BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/ Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.

关 键 词：TGF-Β SMAD CROSS-TALK signaling pathway 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]