流行性出血热患者血清IL-12,IL-6,TNF浓度检测分析及临床意义  

Alterations of IL-12、IL-6 、TNF and clinical significance in Epidemic Hemorrhagic Fever

作　　者：李方春[1] 聂永鹏[1] 吴南珍[1] 

机构地区：[1]江西省丰城市人民医院,丰城331100

出　　处：《江西医药》2008年第12期1284-1286,共3页Jiangxi Medical Journal

摘　　要：目的观察轻型和重型流行性出血热患者血清中,IL-12,IL-6,TNF的改变及临床意义。方法收集流行性出血热轻型和重型病人四期血液,用酶联免疫方法(ELISA)等方法检测炎症因子,并与正常人进行比较。结果发热期:轻型和重型与对照组比较,IL-12均明显增高(P均<0.05);重型与对照组比较,TNF明显增高(P<0.05)。少尿期:轻型和重型与对照组比较,IL-12明显增高(P均<0.05);轻型和重型与对照组比较,TNF明显增高(P均<0.05)。多尿期:轻型和重型与对照组比较,IL-12明显增高(P<0.01);轻型与对照组比较,IL-6明显增高(P<0.01)。恢复期:轻型和重型与对照组比较,IL-12明显增高(P均<0.05);轻型和重型在四期的比较:IL-12,IL-6和TNF均有显著的差异性(P均<0.05)。结论检测IL-12,IL-6,TNF等炎症因子对于流行性出血热的临床疾病严重程度有重要的意义。Objective To study Alterations of IL-12,IL-6 ,TNF and clinical significance in Epidemic Hemorrhagic Fever.Methods To collect four stage blood serum samples in patients with mild and severe EHF.and detected IL-12,IL-6,TNF by ELISA,then Compared with those of normal persons.Results IL-12,IL-6,TNF in patients with mild and severe EHF are significance increase Compared with those of noruaal persons.Conclusions To detect IL-12,IL-6 and TNF in blood serum of patients with EHF for the degree of clinical disease is very significant.

关 键 词：流行性出血热 IL-12 IL-6 TNF 

分 类 号：R512[医药卫生—内科学]