诺拉曲特(Nolatrexed)合成工艺的研究进展  

Advance in Research on Synthesis of Nolatrexed

作　　者：张成江[1,2] 欧阳贵平[1] 赵云[1] 

机构地区：[1]贵州大学精细化工研究开发中心,贵州贵阳550025 [2]遵义医学院药学系,贵州遵义563003

出　　处：《精细化工中间体》2008年第6期1-4,共4页Fine Chemical Intermediates

摘　　要：诺拉曲特(Nolatrexed)是一种新型的、水溶性的、非经典的高效胸苷酸合成酶(TS)抑制剂,其合成工艺的研究近年来受到广泛关注。笔者介绍了目前国内外该化合物合成工艺的最新进展,分析了各合成工艺的优缺点,并对其合成工艺的发展作了展望。Nolatrexed is a new non-classical, water-soluble and high-efficient thymidylate synthase （TS） inhibitor. and has now been attracting great attentions. The latest progress in the synthetic technology of nolatrexed was reviewed in the paper. The merits and limitations of every synthetic technology were analyzed. The prospect and future development trend of the synthetic technology of nolatrexed were proposed as well.

关 键 词：诺拉曲特(Nolatrexed) 合成工艺 优化改进 研究进展 

分 类 号：R979.1[医药卫生—药品]