催化加氢法绿色合成N-(3-氨基-4-甲氧基苯基)乙酰胺  

Catalytic Hydrogenation for the Green Synthesis of N-(3-Amino-4-methoxyphenyl)acetamide

作　　者：张群峰[1] 吕井辉[1] 马磊[1] 卢春山[1] 许孝良[1] 梁秋霞[1] 李小年[1] 

机构地区：[1]浙江工业大学工业催化研究所,绿色化学合成技术国家重点实验室培育基地,浙江杭州310032

出　　处：《精细化工中间体》2008年第6期41-43,共3页Fine Chemical Intermediates

基　　金：浙江省科技厅绿色化工重大专项(2005C11023-01)。

摘　　要：N-(3-氨基-4-甲氧基苯基)乙酰胺是生产偶氮型分散染料的一类重要中间体。现有的工业生产方法仍全部采用铁粉还原。笔者开发了一种高效的Pd/C催化剂,分别选用甲醇和水作为反应溶剂,实现了高活性、高选择性和高稳定性地催化加氢制备N-(3-氨基-4-甲氧基苯基)乙酰胺。为了抑制原料和产物在水溶液中的副反应,添加少量碱性助剂可以提高目标产物的选择性,最高达到99.3%。N-（3-Amino-4-methoxyphenyl）acetamide is an important intermediate for the production of azo disperse dyes, while it is still produced by reduction with iron powder in industry currently. A novel Pd/C catalyst with high activity, high selectivity and good stability developed by our group was used for the hydrogenation of N-（3-nitro-4- methoxyphenyl）acetamide into N-（3-amino-4-methoxyphenyl）acetamide in methanol and water, respectively. The hydrolyzations of reactant and product were decreased in the presence of little basic agent, and the selectivity of 99.3% can be obtained.

关 键 词：液相催化加氢 N(3-氨基—4-甲氧基苯基)乙酰胺 PD/C催化剂 高活性 高选择性 高稳定性 

分 类 号：O625.632[理学—有机化学]