生脉散复方化学的动态变化与药效关系的研究——生脉散复方化学的研究(Ⅱ)  

A Research on Chemical Dynamic Changes and Drug Efficacy of SMS Compound Prescription Chemical Researches on SMS Prescription(Ⅱ)

作　　者：朱丹妮[1] 李志明[1] 严永清[1] 朱景刚 

机构地区：[1]中国药科大学中药研究所

出　　处：《中国中药杂志》1998年第5期291-293,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：为进一步探讨５－羟甲基－２－糠醛（５－ＨＭＦ）在生脉散各配伍组中的含量变化，用高效液相色谱法测定了不同配伍组中５－ＨＭＦ的含量，并测定了不同煎煮时间，煎煮次数及不同比例的麦冬与五味子配伍对５－ＨＭＦ含量的影响。结果表明５－ＨＭＦ是麦冬与五味子共煎过程中生成的，含量随麦冬的增加而增加，以煎煮１．５ｈ为最高，且前２次煎煮即提取完全。The content changes of 5hydroxymethy12furaldehyde(5HMF),a new compound reported in the previous paper,in eight prescriptions of different composition were further determined by HPLC with a view to find the chemical dynamic changes and compatibility of medicines.The contents of 5HMF in different combinations of Radix Ophiopogonis and Fructus Schisandrae,different boiling times and boiling frequency were examined. The results indicated that 5HMF was produced in the boiling process of Radix Ophiopogonis and Fructus Schisandra combined.The contents of 5HMF would increase with the increase of Radix Ophiopogonis amount,reaching the highest value after 1.5h boiling and two times of boiling.

关 键 词：生脉散 羟甲基 糠醛 动态变化 药理学 配伍 

分 类 号：R285.5[医药卫生—中药学] R289.1[医药卫生—中医学]