血管升压素及其拮抗剂在急诊医学中的作用  

Roles of vasopressin and its antagonists in acute medical care

作　　者：李培杰[1] 杜强 曹雯[1] 

机构地区：[1]兰州大学第二医院,兰州730030 [2]水电四局刘家峡职工医院

出　　处：《中国急救医学》2008年第12期1126-1128,共3页Chinese Journal of Critical Care Medicine

摘　　要：血管升压素是由视丘下部产生、垂体后叶分泌的含9个氨基酸组成的短肽。Vaso-pressin拮抗剂可促进电解质液排泄。既往,Vasopressin仅作为抗利尿剂用于治疗尿崩症,但现在常作为血管升压剂用于各种疾病状态,本文对Vasopressin在器官移植、心搏骤停、脓毒症及出血性休克的应用和疗效评价作一综述,同时,介绍三种选择性Vasopressin拮抗剂在充血性心里衰竭、低钠血症和多囊肾的应用进展。Vasopressin is a small polypeptide of nine amino acids produced by the hypothalamus and secreted from the posterior pituitary gland. Vasopressin antagonists promote the excretion of electrolyte solution. In the past, vasopressin was used as antidiuretic agents to treat diabetes insipidus, but it is now used as a vasopressin in a variety of disease states. We will summarize the application and curative effect of vasopressin in organ transplantation, cardiac arrest, sepsis, hemorrhagic shock and illustrate the advances of three selective vasopressin- receptor antagonists in heart failure, hyponatremia, polycystic kidney disease.

关 键 词：血管升压素 血管升压素受体拮抗剂 急诊医学 

分 类 号：R459.7[医药卫生—急诊医学]